149070-47-3Relevant academic research and scientific papers
Synthesis and biological properties of hydroxythioether fatty acids related to leukotrienes: antagonists and agonists of slow-reacting substance of anaphylaxis (SRS-A)
Ho, W,Hageman, W E,Stanley, K G,Gallant, W R,Cherry, D A,et al.
, p. 3 - 12 (2007/10/02)
A series of 6-hydroxy-7-thioether and 6-thioether-7-hydroxy derivatives of commercially available petroselinic acid and 5-hydroxy-6-thioether derivatives of fatty acids containing an aromatic moiety were synthesized.Several of the compounds have exhibited SRS-A antagonist (eg, 5, 10)/agonist (eg, 34, 35) activity.Compound 5 antagonized SRS-A-induced contractions of the isolated guinea pig ileum with IC50 = 0.09 μM. hydroxythioether fatty acids / SRS-A / antagonist / agonist / peptidoleukotriene analogs
