149082-03-1

Basic information

• Product Name: 3,5-Dimethyl-2-hydroxymethyl-4-nitropyridine
• Synonyms: 3,5-DIMETHYL-2-HYDROXYMETHYL-4-NITROPYRIDINE;(3,5-DIMETHYL-4-NITRO-2-PYRIDYL)METHAN-1-OL;3,5-(DIMETHYL-4-NITRO-2-PYRIDYL)METHANOL;3,5-DIMETHYL-4-NITROPYRIDINE-2-METHANOL;2-HYDROXYMETHYL-3,5-DIMETHYL-4-NITROPYRIDINE;(3,5-dimethyl-4-nitro-2-pyridyl)-1-methanol;3,5-Dimethyl-4-Nitro-2-Hydroxymethyl Pyridine;2-hydromethyl-3,5-dimethyl-4-nitro-pyridine
• CAS NO: 149082-03-1
• Molecular Formula: C8H10N2O3
• Molecular Weight: 182.18
• EINECS: -0
• Product Categories: Pyridines derivates;C7 and C8;Heterocyclic Building Blocks;Pyridines;OLED materials,pharm chemical,electronic
• Mol File: 149082-03-1.mol
• Article Data: 4

Chemical Properties

• Melting Point: 66-70 °C(lit.)
• Boiling Point: 349.7 °C at 760 mmHg
• Flash Point: 165.3 °C
• Appearance: /
• Density: 1.293 g/cm³
• Vapor Pressure: 1.72E-05mmHg at 25°C
• Refractive Index: 1.581
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: soluble in Methanol
• PKA: 12.97±0.10(Predicted)
• CAS DataBase Reference: 3,5-Dimethyl-2-hydroxymethyl-4-nitropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Dimethyl-2-hydroxymethyl-4-nitropyridine(149082-03-1)
• EPA Substance Registry System: 3,5-Dimethyl-2-hydroxymethyl-4-nitropyridine(149082-03-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: 2811
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 149082-03-1(Hazardous Substances Data)

Usage

General Description

3,5-Dimethyl-2-hydroxymethyl-4-nitropyridine is a chemical compound with the molecular formula C7H8N2O4. It is a yellow crystalline solid that is used in the synthesis of pharmaceuticals and agricultural chemicals. 3,5-Dimethyl-2-hydroxymethyl-4-nitropyridine is known for its nitro group and hydroxymethyl group, which make it useful in organic synthesis as a building block for more complex molecules. It is also used as a reagent in chemical research and has potential applications in the development of new drugs and agrochemicals. Additionally, 3,5-Dimethyl-2-hydroxymethyl-4-nitropyridine has been the subject of research for its potential biological and pharmacological properties, making it a versatile and important chemical in the field of organic chemistry.

InChI:InChI=1/C8H10N2O3/c1-5-3-9-7(4-11)6(2)8(5)10(12)13/h3,11H,4H2,1-2H3

Upstream product

• 74409-42-0 2,3,5-trimethylpyridine 1-oxide 
• 695-98-7 2,3,5-trimethyl-pyridine 
• 86604-79-7 2,3,5-trimethyl-4-nitropyridine N-oxide 
• 142885-95-8 2-acetyloxymethyl-3,5-dimethyl-4-nitropyridine 

Downstream Products

• 368890-24-8 (3,5-dimethyl-4-nitropyridin-2-yl)methyl 4-methylbenzenesulfonate 

Relevant articles and documents

Improved synthetic approach to tenatoprazole

An improved synthetic approach to tenatoprazole 1 is described. It started from 2,3,5-trimethyl-4-nitropyridine-N-oxide 2 with acetic anhydride via rearrangement and hydrolysis to give 3, Chlorination with SOCl2 yielded 2-chloromethyl-3,5-dimethyl-4-nitropyridine hydrochloride 4, then 4 condensed with 2-mercapto-5-methoxy imidazole [4,5-b]pyridine 5 to give 5-methoxy-2-[(4-nitro-3,5-dimethyl-2-pyridinyl)methylthio]imidazole[4,5-b] pyridine 6. At last the title compound 1 was produced by two methods: 6 was oxidized with MCPBA and then methoxylated with CH3ONa to give 1 and 6 was first methoxylated with CH3ONa and then oxidized with MCPBA to give 1. The overall yield is around 26% for both five-step syntheses. Copyright Taylor & Francis Group, LLC.

Intermediates and an improved process for the preparation of Omeprazole employing the said intermediates

This invention relates to an improved process for the preparation of Omeprazole of the formula-I starting from 4-nitro-2,3,5-trimethylpyridine-N-oxide and through novel intermediates 2-hydroxymethyl-3,5-dimethyl-4-nitro pyridine of the formula II and novel 2-chloromethyl-3,5-dimethyl-4-nitro pyridine of the formula III. This invention also relates to processes for the preparation of the above said novel intermediates. Omeprazole is one of the world's widely used drugs for the treatment of ulcer diseases. This compound acts by irreversible inhibition of the H+K+ATPase enzyme, which is part of the proton pump located in the parietal cell of the stomach wall.