149097-44-9

Upstream product

• 38559-49-8 Deoxyguanosine 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 961-07-9 2'-Deoxyguanosine 

Downstream Products

• 305819-90-3 2-Amino-9-[(2R,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-4-oxo-tetrahydro-furan-2-yl]-1,9-dihydro-purin-6-one 
• 149097-47-2 benzyl 2'-deoxy-N²-dimethylaminomethylene-5'-O-phosphonomethyl-3'-O-(tetrahydro-2H-pyran-2-yl)guanosine 
• 305820-00-2 9-(5-O-tert-butyldiphenylsilyl-2-deoxy-3-C-phosphono-β-D-threo-pentofuranosyl)guanine 

Relevant academic research and scientific papers

NUCLEOTIDE CLEAVABLE LINKERS AND USES THEREOF

Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof for sequencing a nucleic acid.

THERMALLY-CLEAVABLE PROTECTING AND LINKER GROUPS

The present invention relates to chemical linkers and protecting groups, compounds and compositions containing the chemical linkers or protecting groups, and intermediates and processes that can be used to prepare them. The chemical linkers and protecting groups are based on pyrrolidine and piperidine activating groups, which undergo intramolecular cyclisation upon heating with release of carbon dioxide, thereby releasing the organic compound from a substrate. In particular, those chemical linkers and protecting groups are useful in the solid phase synthesis of oligonucleotides according to the following representative schemes.

Diastereoselective synthesis of α-substituted-γ-butyrolactones of nucleosides via [1,5]-c,h insertion reactions of α-diazomalonates of nucleosides

Diastereoselective and regioselective [1,5]-C,H insertion reactions of 2'-deoxy-3'-diazomalonate nucleosides afforded τ-butyrolactones of nucleosides as chiral synthons for the preparation of 2'-C-branched nucleosides.