149105-06-6

Basic information

• Product Name: ((4-BROMO-3-METHYLPHENYL)CARBONYL)MORPHOLINE
• Synonyms: Methanone, (4-bromo-3-methylphenyl)-4-morpholinyl-
• CAS NO: 149105-06-6
• Molecular Formula: C₁₂H₁₄BrNO₂
• Molecular Weight: 284.15
• Mol File: 149105-06-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 424.5±45.0 °C(Predicted)
• Appearance: /
• Density: 1.434±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -1.81±0.20(Predicted)
• CAS DataBase Reference: ((4-BROMO-3-METHYLPHENYL)CARBONYL)MORPHOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: ((4-BROMO-3-METHYLPHENYL)CARBONYL)MORPHOLINE(149105-06-6)
• EPA Substance Registry System: ((4-BROMO-3-METHYLPHENYL)CARBONYL)MORPHOLINE(149105-06-6)

Safety Data

• Hazardous Substances Data: 149105-06-6(Hazardous Substances Data)

Usage

General Description

((4-Bromo-3-methylphenyl)carbonyl)morpholine is a chemical compound with the molecular formula C13H16BrNO2. It is a brominated morpholine derivative, containing a morpholine ring with a carbonyl group and a 4-bromo-3-methylphenyl group attached. ((4-BROMO-3-METHYLPHENYL)CARBONYL)MORPHOLINE is used in the synthesis of pharmaceuticals and agrochemicals. It has been found to exhibit insecticidal and acaricidal activity, making it useful in pest control applications. Additionally, it has potential as a building block in the development of new drugs and other organic compounds. However, due to its potential for toxicity and environmental impact, careful handling and disposal practices are recommended when working with ((4-bromo-3-methylphenyl)carbonyl)morpholine.

Upstream product

• 110-91-8 morpholine 
• 21900-25-4 4-bromo-3-methylbenzoyl chloride 
• 7697-28-1 4-bromo-3-methylbenzoic acid 

Relevant articles and documents

Design of New Ligands for the Palladium-Catalyzed Arylation of α-Branched Secondary Amines

In Pd-catalyzed C-N cross-coupling reactions, α-branched secondary amines are difficult coupling partners and the desired products are often produced in low yields. In order to provide a robust method for accessing N-aryl α-branched tertiary amines, new catalysts have been designed to suppress undesired side reactions often encountered when these amine nucleophiles are used. These advances enabled the arylation of a wide array of sterically encumbered amines, highlighting the importance of rational ligand design in facilitating challenging Pd-catalyzed cross-coupling reactions.

SUBSTITUTED TRIAZOLOPYRIDINES

The present invention relates to substituted triazolopyridine compounds of general formula (I) : in which R1, R2, R3, R4, and R5 are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease of uncontrolled cell growth, proliferation and/or survival as well as to the use of intermediate compounds for the preparation of said compounds.