149116-77-8

Basic information

• Product Name: S-Sulindac Sulfoxide
• Synonyms: (1Z)-5-Fluoro-2-Methyl-1-[[4-[(S)-Methylsulfinyl]phenyl]Methylene]-1H-indene-3-acetic Acid;(S)-Sulindac;S-Sulindac Sulfoxide
• CAS NO: 149116-77-8
• Molecular Formula: C₂₀H₁₇FO₃S
• Molecular Weight: 356.4105832
• Product Categories: Chiral Reagents;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 149116-77-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 581.6±50.0 °C(Predicted)
• Appearance: /
• Density: 1.38±0.1 g/cm3(Predicted)
• PKA: 4.26±0.10(Predicted)
• CAS DataBase Reference: S-Sulindac Sulfoxide(CAS DataBase Reference)
• NIST Chemistry Reference: S-Sulindac Sulfoxide(149116-77-8)
• EPA Substance Registry System: S-Sulindac Sulfoxide(149116-77-8)

Safety Data

• Hazardous Substances Data: 149116-77-8(Hazardous Substances Data)

Usage

Uses

(S)-Sulindac is the S-epimer metabolite of Sulinac (S699215). (S)-Sulindac increases the activity of the P 450 system better than (R)-Sulindac, but both epimers increase primarily the enzymes that oxidize (R)-Sulindac.

Upstream product

• 49627-27-2 5-fluoro-2-methyl-1-(4-methylsulfanylbenzylidene)-3-indenylacetic acid 

Downstream Products

• 144498-50-0 {6-Fluoro-3-[1-(4-methanesulfinyl-phenyl)-meth-(E)-ylidene]-2-methyl-3H-inden-1-yl}-methanol 
• 144498-51-1 6-Fluoro-3-[1-(4-methanesulfinyl-phenyl)-meth-(E)-ylidene]-2-methyl-3H-indene-1-carbaldehyde 
• 144498-49-7 6-Fluoro-3-[1-(4-methanesulfonyl-phenyl)-meth-(E)-ylidene]-2-methyl-3H-indene-1-carbaldehyde 
• 144498-48-6 {6-Fluoro-3-[1-(4-methanesulfonyl-phenyl)-meth-(E)-ylidene]-2-methyl-3H-inden-1-yl}-methanol 
• 41201-75-6 6-Fluoro-3-[1-(4-methanesulfinyl-phenyl)-meth-(E)-ylidene]-2-methyl-3H-indene-1-carboxylic acid 

Relevant articles and documents

Catalyst-free visible light-mediated selective oxidation of sulfides into sulfoxides under clean conditions

A facile and efficient visible-light-mediated method for directly converting sulfides into sulfoxides under clean conditions without using any photocatalysts is reported. This method exhibited favourable compatibility with functional groups and afforded a series of sulfoxides with high selectivity and yields. Moreover, in order to shed more light on such a transformation, detailed mechanism studies were carried out both experimentally and theoretically. The readily accessible, low-cost and eco-friendly nature of the developed method will endow it with attractive applications in chemical synthesis.

Process for the preparation of organic compounds containing a sulfinyl or sulfonyl group

A process for the oxidation of thioethers to sulfoxides or sulfones or for the oxidation of sulfoxides to sulfones by treatment of thioethers or sulfoxides with an oxidizing amount of ε-phthalimidoperhexanoic acid is particularly useful for the preparation of compounds of industrial interest, in particular pharmaceuticals for human or veterinary use.