1491167-97-5

Basic information

• Product Name: methyl (2-(2-(cyclohexylmethylene)hydrazono)-4-oxothiazolidin-5-ylidene)acetate
• CAS NO: 1491167-97-5
• Molecular Weight: 295.362
• Mol File: 1491167-97-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl (2-(2-(cyclohexylmethylene)hydrazono)-4-oxothiazolidin-5-ylidene)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (2-(2-(cyclohexylmethylene)hydrazono)-4-oxothiazolidin-5-ylidene)acetate(1491167-97-5)
• EPA Substance Registry System: methyl (2-(2-(cyclohexylmethylene)hydrazono)-4-oxothiazolidin-5-ylidene)acetate(1491167-97-5)

Safety Data

• Hazardous Substances Data: 1491167-97-5(Hazardous Substances Data)

Upstream product

• 3183-63-9 cyclohexanecarbaldehyde-semicarbazone 
• 762-42-5 dimethyl acetylenedicarboxylate 
• 2043-61-0 cyclohexanecarbaldehyde 

Relevant articles and documents

Synthesis and antiviral activity of new substituted methyl [2-(arylmethylene-hydrazino)-4-oxo-thiazolidin-5-ylidene]acetates

A series of new methyl [2-(arylmethylene-hydrazono)-4-oxo-thiazolidin-5- ylidene]acetates (5a-o) were synthesized via cyclocondensation of thiosemicarbazones (3a-o) with dimethyl but-2-ynedioate (4) in good yields under solvent-free conditions. The environmentally friendly solvent-free protocol overcomes the limitations associated with the customary protracted solution phase synthesis and afforded the title compounds in a few minutes. Compounds 5b-i and 5h-o were evaluated for their antiviral activity against the replication activity of HIV-1 and HIV-2 in MT-4 using the MTT assay. The same compounds were also evaluated in vitro for their selective antiviral activity against hepatitis C virus (HCV) in the Huh 5-2 replicon system (type 1b, Con1 strain).