149137-92-8

Upstream product

• 3938-83-8 (S)-4-amino-2-hydroxybutanoic acid 
• 4457-32-3 4-nitrobenzyl chloroformate 

Downstream Products

• 1154758-37-8 (N-hydroxy-5-norbornene-2,3-dicarboxyl-imido)-N-PNZ-4-amino-2(S)-hydroxy-butanoate 
• 1154758-50-5 6'-trifluoroacetyl-2',3-diPNZ-1-(N-PNZ-4-amino-2(S)-hydroxy-butyryl)-sisomicin 
• 1154758-40-3 2',3-diPNZ-1-(N-PNZ-4-amino-2(S)-hydroxy-butyryl)-3''-Boc-sisomicin 
• 1154758-53-8 6'-trifluoroacetyl-2',3-diPNZ-1-(N-PNZ-4-amino-2(S)-hydroxy-butyryl)-3''-Boc-sisomicin 
• 1154759-12-2 6'-(2-hydroxy-propanol)-2',3-diPNZ-1-(N-PNZ-4-amino-2(S)-hydroxy-butyryl)-3''-Boc-sisomicin 

Relevant academic research and scientific papers

TREATMENT OF URINARY TRACT INFECTIONS WITH ANTIBACTERIAL AMINOGLYCOSIDE COMPOUNDS

A method for treating a urinary tract infection in a mammal in need thereof is disclosed, the method comprising administering to the mammal an effective amount of an antibacterial aminoglycoside compound.

ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS

Compounds of structure (I): having antibacterial activity are disclosed, including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R8 and R9 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

CARBEPENEM DERIVATIVES

Carbapenem derivatives which may be utilized as antibiotics and which show strong antibacterial activity against various bacterial strains including Pseudomonas aeruginosa. The compounds containing the derivatives are quite safe and are also stable against hydrolases such as dehyropeptidase (DHP)