149139-36-6

Basic information

• Product Name: 1H-Pyrazole-1-carboxylicacid,5-amino-,methylester(9CI)
• Synonyms: 1H-Pyrazole-1-carboxylicacid,5-amino-,methylester(9CI);5-Amino-1H-pyrazole-1-carboxylic acid methyl ester
• CAS NO: 149139-36-6
• Molecular Formula: C5H7N3O2
• Molecular Weight: 141.13
• Product Categories: AMINOACID;CARBOXYLICESTER
• Mol File: 149139-36-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 295.9±32.0 °C(Predicted)
• Appearance: /
• Density: 1.41
• PKA: 1.33±0.10(Predicted)
• CAS DataBase Reference: 1H-Pyrazole-1-carboxylicacid,5-amino-,methylester(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole-1-carboxylicacid,5-amino-,methylester(9CI)(149139-36-6)
• EPA Substance Registry System: 1H-Pyrazole-1-carboxylicacid,5-amino-,methylester(9CI)(149139-36-6)

Safety Data

• Hazardous Substances Data: 149139-36-6(Hazardous Substances Data)

Usage

Structure

1H-Pyrazole-1-carboxylic acid, 5-amino-, methyl ester

Type

Methyl ester derivative of 1H-pyrazole-1-carboxylic acid

Uses

Synthesis of pharmaceuticals and agrochemicals

Potential activities

Biological and pharmacological activities (further research needed)

Importance in production

Used as an intermediate in the production of various organic compounds

Safety measures

Handle with proper care and safety measures due to potential hazards.

Relevant articles and documents

Cyanoacetaldehyde - New Synthetic Applications of an Old Compound Syntheses with Nitriles, XCI

Various reactions of cyanoacetaldehyde (1), freshly prepared by ozonization of (E)-1,4-dicyano-2-butene or allylcyanide, are described.Thus, conversion of 1 with anilines gave β-phenylaminoacrylonitriles 2a-e.Reaction of 1 with hydrazines led to the corresponding hydrazones 3a-e, which could be cyclized under alkaline conditions to 5-aminopyrazoles 4a-d.An aldol-type condensation product 5a could be obtained by reaction of 1 with sodiumphenoxide.Treatment of 1 with dimethylformamide-dimethylacetal led to the formation of (E)-3-dimethylamino-2-formylpropenenitrile (6), a very useful synthon in synthetic chemistry.For the determination of the structure of 6 the method of steady state diffferential NOEs was used.Reaction of 6 with hydrazines gave 1-substituted-4-cyanopyrazoles 7a-k. Keywords.Cyanoacetaldehyde; Hydrazones; Cyanopyrazoles; Aminopyrazoles.