149150-92-5Relevant academic research and scientific papers
Application of the Term "Relative Enantioselectivity" as Useful Measure for Comparison of Chiral Catalysts, Demonstrated on Asymmetric Hydrogenation of Amino Acid Precursors
Selke, Ruediger,Facklam, Christine,Foken, Heinrich,Heller, Detlef
, p. 369 - 382 (1993)
The application of the quotient "relative enantioselectivity" Q = q/q' in which q and q' are enantiomeric ratios R/S (or S/R) for two comparable cases of asymmetric synthesis experiments is recommended for comparison of two or more catalysts or other variables like solvents, substrates and cofactors.The importance of this term Q lies in the possibility to form and compare values of enantioselectivity over the whole range from 99.9percent ee (R) to 99.9percent ee (S) in a mathematically correct way and is demonstrated on multiple examples of asymmetric hydrogenation of partly new N-acyl-dehydroamino acid derivatives with a couple of catalysts BF4 1 and BF4 2.Interesting inversions of Q could be discovered for changes of the type of substrate and in dependence of the polarity of solvents.
