149169-34-6

Basic information

• Product Name: 4-(TRIFLUOROMETHOXY)THIOBENZAMIDE
• Synonyms: 4-(trifluoromethoxy)benzene-1-carbothioamide;BUTTPARK 62\07-45;4-(TRIFLUOROMETHOXY)BENZENECARBOTHIOAMIDE;4-(TRIFLUOROMETHOXY)THIOBENZAMIDE;4-(Trifluoromethoxy)thiobenzamide 97%;4-(Trifluoromethoxy)thiobenzamide97%;4-(Trifluoromethoxyl)thiobenzamide
• CAS NO: 149169-34-6
• Molecular Formula: C₈H₆F₃NOS
• Molecular Weight: 221.2
• Mol File: 149169-34-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 124-126°C
• Boiling Point: 245.8°Cat760mmHg
• Flash Point: 102.5°C
• Appearance: /
• Density: 1.414g/cm³
• Vapor Pressure: 0.0281mmHg at 25°C
• Refractive Index: 1.546
• CAS DataBase Reference: 4-(TRIFLUOROMETHOXY)THIOBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(TRIFLUOROMETHOXY)THIOBENZAMIDE(149169-34-6)
• EPA Substance Registry System: 4-(TRIFLUOROMETHOXY)THIOBENZAMIDE(149169-34-6)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-43-22
• Safety Statements: 26-36/37/39-36/37
• Hazardous Substances Data: 149169-34-6(Hazardous Substances Data)

Usage

General Description

4-(TRIFLUOROMETHOXY)THIOBENZAMIDE is an organic compound that contains a thioamide group and a trifluoromethoxy moiety. It has the molecular formula C8H6F3NOS and a molar mass of 223.2 g/mol. The compound is used in the synthesis of pharmaceuticals and agrochemicals, and it exhibits biological activity as a potential antifungal agent. It is also known to possess insecticidal and insect repellent properties. Additionally, 4-(TRIFLUOROMETHOXY)THIOBENZAMIDE is used as an intermediate in the production of other organic compounds and can be found in various chemical databases for research and industrial applications.

InChI:InChI=1/C8H6F3NOS/c9-8(10,11)13-6-3-1-5(2-4-6)7(12)14/h1-4H,(H2,12,14)

Upstream product

• 332-25-2 4-(trifluoromethoxy)benzonitrile 
• 456-71-3 4-trifluoromethoxybenzamide 

Downstream Products

• 886368-15-6 ethyl 2-[4-(trifluoromethoxy)phenyl]-1,3-thiazole-4-carboxylate 
• 187998-69-2 4-methyl-2-{4-[(trifluoromethyl)oxy]phenyl}-1,3-thiazole-5-carboxylic acid 
• 343322-26-9 2-methyl-2-[4-{[(4-methyl-2-[4-trifluoromethoxyphenyl]-thiazol-5-ylcarbonyl)amino]methyl}phenoxy]propionic acid ethyl ester 
• 343322-56-5 ethyl 4-methyl-2-{4-[(trifluoromethyl)oxy]phenyl}-1,3-thiazole-5-carboxylate 

Relevant articles and documents

Synthesis of imidazo[1,2-: C] thiazoles through Pd-catalyzed bicyclization of tert-butyl isonitrile with thioamides

Building new biological molecules is challenging. Herein, imidazo[1,2-c]thiazoles were synthesized as a new class of heterobicyclic analogs through Pd-catalyzed cascade bicyclization from isonitriles with thioamides. The bicyclic scaffolds were constructed by inserting three molecules of isonitrile into two molecules of thioamide and then cyclizing them in a one-pot procedure. In vitro antitumor studies of these new compounds were conducted by using the MTT assay, and compound 3c showed excellent inhibitory effects against HepG2 at 7.06 ± 0.68 μM.

NITROIMIDAZOLE COMPOUNDS

The present invention relates to certain nitroimidazole compounds, which have interesting pharmaceutical properties. In particular, the compounds are useful in the treatment and/or prevention of infections such as those caused by Mycobacterium tuberculosis, Trypanosoma cruzi or Leishmania donovani. The invention also relates to pharmaceutical compositions containing the compounds, as well as processes for their preparation.