149169-34-6

Usage

Uses

Used in Pharmaceutical Synthesis:
4-(TRIFLUOROMETHOXY)THIOBENZAMIDE is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Production:
In the agrochemical industry, 4-(TRIFLUOROMETHOXY)THIOBENZAMIDE is utilized as a component in the creation of products designed to protect crops from fungal infections, leveraging its antifungal properties.
Used as an Antifungal Agent:
4-(TRIFLUOROMETHOXY)THIOBENZAMIDE is employed as an antifungal agent for its effectiveness in combating fungal growth, which is crucial in both medical and agricultural settings to prevent diseases and crop losses.
Used in Insect Control:
4-(TRIFLUOROMETHOXY)THIOBENZAMIDE is used as an insecticide and insect repellent, capitalizing on its insecticidal properties to manage and control insect populations that can be harmful to crops or transmit diseases.
Used in Organic Compound Production:
4-(TRIFLUOROMETHOXY)THIOBENZAMIDE serves as an intermediate in the production of other organic compounds, contributing to the synthesis of a wide range of chemical products used across various industries.

InChI:InChI=1/C8H6F3NOS/c9-8(10,11)13-6-3-1-5(2-4-6)7(12)14/h1-4H,(H2,12,14)

Upstream product

• 456-71-3 4-trifluoromethoxybenzamide 
• 332-25-2 4-(trifluoromethoxy)benzonitrile 

Downstream Products

• 343322-56-5 ethyl 4-methyl-2-{4-[(trifluoromethyl)oxy]phenyl}-1,3-thiazole-5-carboxylate 
• 886368-15-6 ethyl 2-[4-(trifluoromethoxy)phenyl]-1,3-thiazole-4-carboxylate 
• 187998-69-2 4-methyl-2-{4-[(trifluoromethyl)oxy]phenyl}-1,3-thiazole-5-carboxylic acid 
• 343322-26-9 2-methyl-2-[4-{[(4-methyl-2-[4-trifluoromethoxyphenyl]-thiazol-5-ylcarbonyl)amino]methyl}phenoxy]propionic acid ethyl ester 

Relevant academic research and scientific papers

Synthesis of imidazo[1,2-: C] thiazoles through Pd-catalyzed bicyclization of tert-butyl isonitrile with thioamides

Building new biological molecules is challenging. Herein, imidazo[1,2-c]thiazoles were synthesized as a new class of heterobicyclic analogs through Pd-catalyzed cascade bicyclization from isonitriles with thioamides. The bicyclic scaffolds were constructed by inserting three molecules of isonitrile into two molecules of thioamide and then cyclizing them in a one-pot procedure. In vitro antitumor studies of these new compounds were conducted by using the MTT assay, and compound 3c showed excellent inhibitory effects against HepG2 at 7.06 ± 0.68 μM.

A efficient protocol for the synthesis of thioamides in [DBUH][OAc] at room temperature

A novel, simple and eco-friendly method to synthesize thioamides from aryl nitriles and sodium sulfide (Na2S·9H2O) catalyzed by 1,8-diazabicyclo[5,4,0]undec-7-enium acetate ([DBUH][OAc]) ionic liquid (IL) at room temperature was developed in this paper. In this reaction, readily available inorganic salt (Na2S·9H2O) serves as the sulfur source, and various functional groups of aryl nitriles were well tolerated at room temperature. In addition, the products were easily separated from the IL which could be reused at least five times without considerable loss of its activity and applied in the green, concise synthesis of ethionamide.

NITROIMIDAZOLE COMPOUNDS

The present invention relates to certain nitroimidazole compounds, which have interesting pharmaceutical properties. In particular, the compounds are useful in the treatment and/or prevention of infections such as those caused by Mycobacterium tuberculosis, Trypanosoma cruzi or Leishmania donovani. The invention also relates to pharmaceutical compositions containing the compounds, as well as processes for their preparation.