149172-64-5

Basic information

• Product Name: 3-amino-2-(4-chlorophenyl)nitropropane
• Synonyms: 3-amino-2-(4-chlorophenyl)nitropropane
• CAS NO: 149172-64-5
• Molecular Formula: C₉H₁₁ClN₂O₂
• Molecular Weight: 214.65
• Mol File: 149172-64-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 347.5°Cat760mmHg
• Flash Point: 164°C
• Appearance: /
• Density: 1.278g/cm³
• Vapor Pressure: 5.35E-05mmHg at 25°C
• Refractive Index: 1.567
• CAS DataBase Reference: 3-amino-2-(4-chlorophenyl)nitropropane(CAS DataBase Reference)
• NIST Chemistry Reference: 3-amino-2-(4-chlorophenyl)nitropropane(149172-64-5)
• EPA Substance Registry System: 3-amino-2-(4-chlorophenyl)nitropropane(149172-64-5)

Safety Data

• Hazardous Substances Data: 149172-64-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H11ClN2O2/c10-9-3-1-7(2-4-9)8(5-11)6-12(13)14/h1-4,8H,5-6,11H2

Upstream product

• 159112-11-5 N-<2-(4-chlorophenyl)-3-nitropropyl>-2,2,2-trifluoroacetamide 
• 20754-21-6 methyl 3-(4-chlorophenyl)propenoate 
• 159112-23-9 3-(4-chlorophenyl)-4-nitrobutanoic acid 
• 101466-69-7 methyl (+/-)-3-(4-chlorophenyl)-4-nitrobutanoate 

Relevant articles and documents

Potential GABAB Receptor Antagonists. VII. The Synthesis of 2-(4-Chlorophenyl)-3-nitropropan-1-amine and Related Analogues of Baclofen

3-Nitro-2-phenylpropan-1-amine and 2-(4-chlorophenyl)-3-nitropropan-1-amine have been synthesized by the addition of nitrous acid to the corresponding trifluoroacetylaminomethylstyrenes followed by reduction of the double bond with sodium borohydride.A more general and efficient route involves the Michael addition of nitroalkane anions to methyl cinnamates followed by Curtius degradation of the corresponding acids. 2-(4-Chlorophenyl)-3-nitropropan-1-amine is a specific agonist of GABA and the GABAB receptor, with about half the activity of racemic baclofen at the isolated guinea pig ileum.Methylation or dimethylation at C3 decreases activity markedly.