14918-68-4Relevant articles and documents
Nouvelles methodes de synthese de la naphtopurpurine (trihydroxy-2,5,8 naphtoquinone-1,4)
Bekaert, Alain,Andrieux, Jean,Plat, Michel
, p. 314 - 316 (2007/10/02)
The condensation of 1,2,4 trimethoxybenzene with maleic anhydride in the presence of AlCl3-NaCl affords, in a single step, naphtopurpurine 1, an important intermediate in the synthesis of naphtoquinone derived natural products.A different synthesis of compound 1 consists in the substitution of the halogen atom in 2-chloro or 2-bromo-naphthazirin by a methoxy group which is subsequently cleaved in an acidic medium or by a Lewis acid.