14919-77-8 Usage
Description
Benserazide is an inhibitor of aromatic L-amino acid decarboxylase (AADC), an enzyme that has dopamine decarboxylase activity. It is also unable to cross the blood-brain barrier. As a result, benserazide blocks the conversion of L-DOPA to dopamine by AADC in the peripheral circulatory system. Benserazide is often combined with L-DOPA in patients with Parkinson’s disease.
Chemical Properties
White Crystalline Solid
Uses
Different sources of media describe the Uses of 14919-77-8 differently. You can refer to the following data:
1. Used as antiparkinsonian. A peripheral decarboxylase inhibitor
2. Antiparkinsonian;DOPA decarboxylase inhibitor
3. Inhibitor of L-aromatic amino acid decarboxylaseBenserazide hydrochloride is used as an antiparkinsonian. It is a peripheral decarboxylase inhibitor. It is used as an inhibitor for aromatic L-aminoacid decarboxylase. Further, it serves as an inhibitor of tyrosine hydroxylase (TH) and Tryptophan hydroxylase (TPH) inhibitor.
Definition
ChEBI: A hydrochloride that is the monohydrochloride salt of benserazide. An aromatic-L-amino-acid decarboxylase inhibitor (DOPA decarboxylase inhibitor) that does not enter the central nervous system, it is used as an adjunct to levodopa in the treatment of park
nsonism. By preventing the conversion of levodopa to dopamine in the periphery, it causes an increase in the amount of levodopa reaching the central nervous system and so reduces the required dose. Benserazide hydrochloride has no antiparkinson actions whe
given alone.
General Description
Benserazide is a peripheral decarboxylase inhibitor.
Biochem/physiol Actions
Inhibitor of L-aromatic amino acid decarboxylase.
Check Digit Verification of cas no
The CAS Registry Mumber 14919-77-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,9,1 and 9 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 14919-77:
(7*1)+(6*4)+(5*9)+(4*1)+(3*9)+(2*7)+(1*7)=128
128 % 10 = 8
So 14919-77-8 is a valid CAS Registry Number.
