149197-97-7

Usage

Uses

Used in Pharmaceutical Applications:
(R)-Phaselic acid is used as a therapeutic agent for its potential anti-inflammatory and anti-cancer effects. Research suggests that it may help in the treatment and management of various inflammatory and cancerous conditions by modulating key signaling pathways involved in these diseases.
Used in Food and Beverage Industry:
(R)-Phaselic acid is used as a natural preservative to extend the shelf life of food products. Its ability to inhibit the growth of harmful bacteria makes it a valuable addition to the industry, offering a healthier alternative to synthetic preservatives.
Used in Wellness Products:
(R)-Phaselic acid is used as an ingredient in wellness products due to its potential to improve cardiovascular health. Its antioxidant properties may contribute to the overall well-being and health of consumers, making it a sought-after component in the development of supplements and health-focused products.

Upstream product

• 102876-69-7 caffeic acid anhydride tetraacetate 
• 1364479-79-7 dimethyl (2S)-2-({(2E)-3-[3,4-bis(acetyloxy)phenyl]prop-2-enoyl}oxy)butanedioate 

Relevant academic research and scientific papers

Synthesis of (+)- and (-)-phaselic acid

The syntheses of both enantiomers of phaselic acid (2-O-caffeoylmalate) are described. The previously unreported acetate-protected caffeic acid anhydride was used with appropriately protected malic acid derivatives as coupling partners to provide fully pr

An approach to the chemotaxonomic differentiation of two European Dog's mercury species: Mercurialis annua L. and M. perennis L.

Mercurialis annua and M. perennis are medicinal plants used in complementary medicine. In the present work, analytical methods to allow a chemotaxonomic differentiation of M. annua and M. perennis by means of chemical marker compounds were established. In addition to previously published compounds, the exclusive presence of pyridine-3-carbonitrile and nicotinamide in CH2Cl2 extracts obtained from the herbal parts of M. annua was demonstrated by GC/MS. Notably, pyridine-3-carbonitrile was identified for the first time as a natural product. Further chromatographic separation of the CH2Cl2 extracts via polyamide yielded a MeOH fraction exhibiting a broad spectrum of side-chain saturated n-alkylresorcinols. While the n-alkylresorcinol pattern was similar for both plant species, some specific differences were observed for particular n-alkylresorcinol homologs. Finally, the investigation of H2O extracts by LC/MS/MS revealed the presence of depside constituents. Whereas, in M. perennis, a mixture of mercurialis acid (=(2R)-[(E)-caffeoyl]-2-oxoglutarate) and phaselic acid (=(E)-caffeoyl-2-malate) could be detected, in M. annua solely phaselic acid was found. By comparison with synthesized enantiomerically pure (2R)- and (2S)-phaselic acids, the configuration of the depside could be determined as (2S) in M. annua and as (2R) in M. perennis.