1492020-34-4

Basic information

• Product Name: (R)-2-bromo-1-(4-(trifluoromethoxy)phenyl)ethanol
• Synonyms: (R)-2-bromo-1-(4-(trifluoromethoxy)phenyl)ethanol
• CAS NO: 1492020-34-4
• Molecular Weight: 285.061
• Mol File: 1492020-34-4.mol

Chemical Properties

• CAS DataBase Reference: (R)-2-bromo-1-(4-(trifluoromethoxy)phenyl)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-bromo-1-(4-(trifluoromethoxy)phenyl)ethanol(1492020-34-4)
• EPA Substance Registry System: (R)-2-bromo-1-(4-(trifluoromethoxy)phenyl)ethanol(1492020-34-4)

Safety Data

• Hazardous Substances Data: 1492020-34-4(Hazardous Substances Data)

Upstream product

• 103962-10-3 2-bromo-1-(4-(trifluoromethoxy)phenyl)ethanone 

Relevant articles and documents

Preparative access to medicinal chemistry related chiral alcohols using carbonyl reductase technology

Libraries of highly enantioenriched secondary alcohols in both enantiomeric forms were synthesised by enzymatic reduction of their parent ketones using selectAZyme carbonyl reductase (CRED) technology. Commercially available CREDs were able to reduce a range of substrate classes efficiently and with very high enantioselectivity. Matching substrate classes to small subsets of CREDs enabled the fast development of preparative bioreductions and the rapid generation of 100-1500 mg samples of chiral alcohols in typically >95% ee and the majority in ≥99.0% ee. The conditions for small scale synthesis were then scaled up to 0.5 kg to deliver one of the chiral alcohols, (S)-1-(4-bromophenyl)-2-chloroethanol, in 99.8% ee and 91% isolated yield.