1492056-97-9

Upstream product

• 80-59-1 Tiglic acid 
• 127481-94-1 1-bromo-4-[[(1,1-dimethylethyl)-diphenylsilyl]-oxy]-benzene 
• 1492056-94-6 (S,E)-ethyl 5-formyl-5-methylhepta-2,6-dienoate 
• 1492056-92-4 (S,E)-ethyl 5-(hydroxymethyl)-5-methylhepta-2,6-dienoate 
• 1492056-91-3 (S,E)-ethyl 5-(((tert-butyldimethylsilyl)oxy)methyl)-5-methylhepta-2,6-dienoate 
• 1492056-89-9 (S)-tert-butyl 3-(((tert-butyldimethylsilyl)oxy)methyl)-3-methylpent-4-enoate 
• 1492056-88-8 (S)-tert-butyl 3-(hydroxymethyl)-3-methylpent-4-enoate 
• 1492056-85-5 (S)-tert-butyl 3-((R)-4-isopropyl-2-oxooxazolidine-3-carbonyl)-3-methylpent-4-enoate 
• 1492056-95-7 (S,2E,6E)-ethyl 7-iodo-5-methyl-5-vinylhepta-2,6-dienoate 
• 35660-94-7 (E)-2-methylbut-2-enoyl chloride 

Downstream Products

• 1492056-98-0 (S,3E,7E)-8-(4-((tert-butyldiphenylsilyl)oxy)phenyl)-2,6-dimethyl-6-vinylocta-3,7-dien-2-ol 
• 178765-49-6 4-((S,1E,5E)-7-hydroxy-3,7-dimethyl-3-vinylocta-1,5-dien-1-yl)phenol 

Relevant academic research and scientific papers

Δ3 Asymmetric synthesis method -2 - hydroxyl psoralen and analogue compound

The invention belongs to the field of chemical synthesis, provides a novel method for synthesizing delta3-2-hydroxybakuchiol and particularly relates to an asymmetric synthesis method for delta3-2-hydroxybakuchiol and analog compounds. The delta3-2-hydroxybakuchiol and the analog compounds, the general formula of which is (I), are synthesized by an asymmetric synthesis route. Problems in the prior art, that the content of the delta3-2-hydroxybakuchiol obtained by extraction and separation from plants is very low, an extraction rate is very low, the delta3-2-hydroxybakuchiol is prone to oxidative deterioration in extraction and separation processes, and the like, are overcome by the method. The method can provide sufficient samples for related pharmaceutical research, and provides good foundations for pharmaceutical research on antibiosis, infection resistance, oxidation resistance, pigment deposition resistance, reduction of bone loss, immunosuppression, liver damage, sedation and hypnosis, and the like. In the formula (I), R1 is selected from 4-hydroxy, 3-hydroxy, 2-hydroxy, hydrogen, 4-methyl, 4-methoxy, 4-trifluoromethyl, 3,4-[d][1,3]dioxole, and 3,4-phenyl; R2 is selected from methyl, ethyl, and butyl; and R3 is selected from vinyl, ethyl and cyclopropyl.

A facile asymmetric synthesis of Δ3-2-Hydroxybakuchiol, Bakuchiol and ent-Bakuchiol

A facile asymmetric synthesis of Δ3-2-Hydroxybakuchiol, Bakuchiol, and ent-Bakuchiol is described through one common intermediate bearing a chiral all-carbon quaternary carbon center, which involves stereoselectively unconjugated alkylation of the α,β-unsaturated imide bearing Evans' auxiliary, Takai-Utimoto reaction, Negishi reaction, and Heck reaction as key steps.