149244-06-4Relevant academic research and scientific papers
Steric acceleration of intramolecular cycloaddition reactions
Orlek, Barry S.,Sammes, Peter G.,Weller, David J.
, p. 8179 - 8194 (2007/10/02)
Use of conformational constraints, induced by different ortho-substituents in 1-allyloxy-2-(substituted)methylbenzenes, where the substituent is a 1,3-dipole such as the azide or 3-oxidopyridinium group, can be employed to accelerate the 1,3-dipolar cycloaddition reaction. In this manner cycloadditions that otherwise do not proceed can be forced to react.
