149245-07-8Relevant academic research and scientific papers
Cu(II)-Catalyzed Construction of Heterobiaryls using 1-Diazonaphthoquinones: A General Strategy for the Synthesis of QUINOX and Related P,N Ligands
Biswas, Aniruddha,Pan, Subarna,Samanta, Rajarshi
, p. 1631 - 1636 (2022/03/14)
An efficient and straightforward method was developed for the synthesis of heterobiaryls using easily available N-oxides and diazonaphthoquinones under cheap Cu(II) catalysis. The developed method offered QUINOX and related congeners in a simple manner. A wide scope of important heterobiaryls was achieved with high site selectivity. The synthesized naphthols were transformed into the privileged related P,N ligands. Suitable resolution methods can directly afford the corresponding axially chiral heterobiaryls.
Synthesis of IAN-type N,N-Ligands via Dynamic Kinetic Asymmetric Buchwald-Hartwig Amination
Ramírez-López, Pedro,Ros, Abel,Romero-Arenas, Antonio,Iglesias-Sigüenza, Javier,Fernández, Rosario,Lassaletta, José M.
supporting information, p. 12053 - 12056 (2016/10/09)
The Pd0-catalyzed coupling of racemic heterobiaryl bromides, triflates, or nonaflates with aryl/alkyl primary amines using QUINAP as the ligand provides the corresponding axially chiral heterobiaryl amines with excellent yields and enantioselectivities. Reactivity and structural studies of neutral and cationic oxidative addition intermediates support a dynamic kinetic asymmetric amination mechanism based on the labilization of the stereogenic axis in the latter and suggest that coordination of the amine to the Pd center is the stereodetermining step.
Synthesis and Resolution of 1-(2-Diphenylphosphino-1-naphthyl)isoquinoline; a P-N Chelating Ligand for Asymmetric Catalysis
Alcock, Nathaniel W.,Brown, John M.,Hulmes, David I.
, p. 743 - 756 (2007/10/02)
A multistep synthesis resulting in a good yield of the title compound has been developed based on the Pd-catalysed coupling of 1-chloroisoquinoline and 2-methoxy-1-naphthylboronic acid (5).The product is converted into the corresponding trifluoromethanesu
