149246-80-0

Basic information

• Product Name: 3-Amino-5-(2-bromophenyl)-1H-pyrazole
• Synonyms: 3-Amino-5-(2-bromophenyl)-1H-pyrazole;5-(2-bromophenyl)-1H-Pyrazol-3-amine
• CAS NO: 149246-80-0
• Molecular Formula: C₉H₈BrN₃
• Molecular Weight: 238.08
• Mol File: 149246-80-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 466.2°C at 760 mmHg
• Flash Point: 235.8°C
• Appearance: /
• Density: 1.645g/cm³
• Vapor Pressure: 7.22E-09mmHg at 25°C
• Refractive Index: 1.689
• PKA: 13.92±0.10(Predicted)
• CAS DataBase Reference: 3-Amino-5-(2-bromophenyl)-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Amino-5-(2-bromophenyl)-1H-pyrazole(149246-80-0)
• EPA Substance Registry System: 3-Amino-5-(2-bromophenyl)-1H-pyrazole(149246-80-0)

Safety Data

• Hazardous Substances Data: 149246-80-0(Hazardous Substances Data)

Usage

General Description

3-Amino-5-(2-bromophenyl)-1H-pyrazole is a chemical compound with the molecular formula C9H8BrN3. It is a pyrazole derivative that contains an amino group and a bromophenyl group. 3-Amino-5-(2-bromophenyl)-1H-pyrazole has potential applications in pharmaceutical research and drug development due to its unique structure and properties. It may exhibit biological activity and could be used as a building block for the synthesis of new drugs or as a reference compound for analytical testing. Research on 3-Amino-5-(2-bromophenyl)-1H-pyrazole is ongoing, and its potential uses and properties are still being explored.

InChI:InChI=1/C9H8BrN3/c10-7-4-2-1-3-6(7)8-5-9(11)13-12-8/h1-5H,(H3,11,12,13)

Upstream product

• 53882-80-7 3-(2-bromophenyl)-3-oxopropanenitrile 

Downstream Products

• 569656-17-3 N-[5-(2-Bromophenyl)-2H-pyrazole-3-yl]-4,4,4-trifluoro-3-oxo-butyramide 
• 1332506-37-2 2-(o-bromophenyl)-6-ethoxycarbonyl-7-methylpyrazolo[1,5-a]pyrimidine 
• 1332506-42-9 6-acetyl-2-(o-bromophenyl)-7-hydroxypyrazolo[1,5-a]pyrimidine 
• 860477-85-6 [5-(2-bromo-phenyl)-2H-pyrazol-3-yl]-thiourea 

Relevant articles and documents

Design, synthesis, and evaluation of 2-aryl-7-(3′,4′-dialkoxyphenyl)-pyrazolo[1,5-a]pyrimidines as novel PDE-4 inhibitors

Described herein is design, synthesis, and biological evaluation of novel series of 2-aryl-7-(3′,4′-dialkoxyphenyl)-pyrazolo[1,5-a]pyrimidines acting as inhibitors of type 4 phosphodiesterase (PDE4) which is known as a good target for the treatment of asthma and COPD. For this purpose, structure optimization was conducted with the aid of structure-based drug design using the known X-ray crystallography. Also, biological effects of these compounds on the target enzyme were evaluated by using in vitro assays, leading to the potent and selective PDE-4 inhibitor (IC50 10 nM).

Methods of treating conditions associated with an EDG-4 receptor

The present invention provides a method of modulating an Edg-4 receptor mediated biological activity in a cell. A cell expressing the Edg-4 receptor is contacted with a modulator of an Edg-4 receptor sufficient to modulate the Edg-4 receptor mediated biol