149246-81-1

Basic information

• Product Name: 5-(3-BROMO-PHENYL)-2H-PYRAZOL-3-YLAMINE
• Synonyms: 3-(3-BROMOPHENYL)-1H-PYRAZOL-5-AMINE;5-(3-BROMO-PHENYL)-2H-PYRAZOL-3-YLAMINE;3-Amino-5-(3-bromophenyl)-1H-pyrazole;5-AMino-3-(3-broMophenyl)pyrazole;3-(3-bromophenyl)-1H-pyrazol-5-amine (en);5-(3-bromophenyl)-1H-Pyrazol-3-amine;EOS-61412
• CAS NO: 149246-81-1
• Molecular Formula: C₉H₈BrN₃
• Molecular Weight: 238.08
• Mol File: 149246-81-1.mol
• Article Data: 10

Chemical Properties

• Melting Point: 149-151°C
• Boiling Point: 470.6°C at 760 mmHg
• Flash Point: 238.4°C
• Appearance: /
• Density: 1.645g/cm³
• Vapor Pressure: 4.99E-09mmHg at 25°C
• Refractive Index: 1.689
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-(3-BROMO-PHENYL)-2H-PYRAZOL-3-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(3-BROMO-PHENYL)-2H-PYRAZOL-3-YLAMINE(149246-81-1)
• EPA Substance Registry System: 5-(3-BROMO-PHENYL)-2H-PYRAZOL-3-YLAMINE(149246-81-1)

Safety Data

• Hazard Codes: Xi,T
• Statements: 25
• Safety Statements: 45
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 149246-81-1(Hazardous Substances Data)

Usage

General Description

5-(3-Bromo-phenyl)-2H-pyrazol-3-ylamine is a chemical compound with the molecular formula C9H8BrN3. It is a pyrazole derivative that contains a bromine-substituted phenyl group and an aminopyrazole group. 5-(3-BROMO-PHENYL)-2H-PYRAZOL-3-YLAMINE has potential applications in pharmaceutical research and development, as it may have biological activity and therapeutic properties. It can be used as a building block or intermediate in the synthesis of various pharmaceutical compounds. The chemical properties and reactivity of 5-(3-Bromo-phenyl)-2H-pyrazol-3-ylamine make it a valuable component in the production of drug candidates and other biologically active molecules. Therefore, it is of interest to researchers in the pharmaceutical and chemical industries for its potential therapeutic applications.

InChI:InChI=1/C9H8BrN3/c10-7-3-1-2-6(4-7)8-5-9(11)13-12-8/h1-5H,(H3,11,12,13)

Upstream product

• 70591-86-5 3-(3-bromophenyl)-3-oxo-propanenitrile 
• 948883-31-6 3-(3-bromo-phenyl)-3-chloro-acrylonitrile 
• 618-89-3 methyl 3-bromobenzoate 
• 18523-22-3 2,3'-dibromoacetophenone 

Downstream Products

• 149246-93-5 2-(3-bromophenyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one 
• 926662-93-3 ethyl 2-(3-bromophenyl)-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylate 
• 1567214-39-4 (2S)-methyl 2-(7-(4-allyl-7-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-2-(3-bromophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate 
• 1567214-42-9 (2S)-methyl 2-(7-(4-allyl-7-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-2-(2‘-(but-3-en-1-yl)-[1,1‘-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate 
• 1567214-60-1 (2S)-methyl 2-(7-(4-allylchroman-6-yl)-2-(3-bromophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate 
• 1567213-38-0 methyl 2-(2-(3-bromophenyl)-7-chloro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)acetate 
• 1567214-64-5 (2S)-methyl 2-(7-(4-allylchroman-6-yl)-2-(2‘-(but-3-en-1-yl)-[1,1‘-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate 
• 1567214-72-5 (2S)-methyl 2-(7-(4-allylchroman-6-yl)-2-(2‘-hydroxy-[1,1‘-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate 
• 1567214-75-8 (2S)-methyl 2-(7-(4-allylchroman-6-yl)-2-(2‘-(allyloxy)-[1,1‘-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate 
• 1567213-41-5 methyl 2-(2-(3-bromophenyl)-7-iodo-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)acetate 
• 1567214-91-8 (S)-methyl 2-(7-(4-allyl-8-fluoro-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-2-(3-bromophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate 
• 1567214-94-1 (S)-methyl 2-(7-(4-allyl-8-fluoro-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-2-(2‘-(but-3-en-1-yl)-[1,1‘-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate 
• 1567215-12-6 methyl 2-(2-(3-bromophenyl)-7-chloro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-hydroxyacetate 
• 1567213-44-8 methyl 2-(2-(3-bromophenyl)-7-iodo-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-hydroxyacetate 

Relevant articles and documents

PYRAZOLOPYRIMIDINE MACROCYCLES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION

The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection.

PYRAZOLOPYRIMIDINE MACROCYCLES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION

The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV integrase, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection.

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