149261-28-9

Upstream product

• 91868-79-0 2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetic acid 
• 131990-97-1 1-(2-Amino-thiazol-4-yl)-2-(5-methyl-2-thioxo-[1,3,4]thiadiazol-3-yl)-ethane-1,2-dione 1-(O-methyl-oxime) 
• 111390-01-3 C₁₃H₁₉N₃O₃S*HI 
• 131990-96-0 (2-Amino-thiazol-4-yl)-[(Z)-methoxyimino]-thioacetic acid S-(5-methyl-[1,3,4]thiadiazol-2-yl) ester 
• 131990-94-8 1-(2-Amino-thiazol-4-yl)-2-(4-methyl-5-thioxo-4,5-dihydro-tetrazol-1-yl)-ethane-1,2-dione 1-(O-methyl-oxime) 
• 103121-85-3 1-[(7-amino-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)methyl]-1-methyl-pyrrolidinium-chloride 

Relevant academic research and scientific papers

NEW CEPHALOSPORIN ACYLATING AGENTS DERIVED FROM SYN-2-(2-AMINOTHIAZOL-4-YL)-2-METHOXYIMINOACETIC ACID. APPLICATION TO THE SYNTHESIS OF CEFEPIME SULFATE

Activation of the title acid 1 as acyl derivatives of 1-methyl-5-mercaptotetrazole (13) and 2-methyl-5-mercapto-1,3,4-thiadiazole (9,14) and subsequent acylation of penultimate 4 (X=Cl, I) gave good yields of cefepime sulfate 5.