149267-64-1

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 24424-99-5 di-tert-butyl dicarbonate 
• 870-46-2 t-butoxycarbonylhydrazine 

Downstream Products

• 149267-65-2 N-1-(tert-butoxycarbonyl)-N-2-<(4-fluorophenyl)methyl>hydrazine 
• 1221501-69-4 6-[1-(4-Fluorobenzyl)-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-4-yl]-2H-1,4-benzoxazin-3(4H)-one 
• 121649-18-1 5-(4-fluorophenyl)-3H-[1,3,4]oxadiazol-2-one 
• 1422157-59-2 N′-[chloro-(4-fluorophenyl)methylene]-tert-butylcarbazate 
• 1221504-07-9 (4-Fluorobenzyl)hydrazine trifluoroacetic acid 
• 1221504-09-1 4-bromo-1-(4-fluorobenzyl)-5-(4-fluorophenyl)-3-methyl-1H-pyrazole 
• 1221504-08-0 1-(4-fluorobenzyl)-5-(4-fluorophenyl)-3-methyl-1H-pyrazole 

Relevant academic research and scientific papers

Synthesis of 5-aryl-3H-[1,3,4]oxadiazol-2-ones from N′-(chloro-aryl- methylene)-tert-butylcarbazates using basic alumina as an efficient and recyclable surface under solvent-free condition

The synthesis of biologically important 5-aryl-3H-[1,3,4]oxadiazol-2-ones has been carried out by heating the easily synthesized N′-(chloro-aryl- methylene)-tert-butylcarbazates on basic alumina surface under solvent-free condition. The dual characteristic of basic alumina as a solid support as well as a nucleophile is successfully exploited in these reactions. The method provides special attributions such as reduced reaction times, easier work-up procedures, and good to excellent yields as well as increased purity of products and most importantly environmentally friendly protocols. The basic alumina is easily recovered and utilized for further reactions several times without serious loss of activity.

Design, synthesis and antiviral activity of novel pyridazines

A series of pyridazines were prepared and evaluated for their anti-HIV activity. The new synthetic route involving a novel rearrangement reaction provided a practical method for the preparation of 5-hydroxypyridazines. The primary bioassay results indicated that most of the pyridazines possess anti-HIV activity. It ought to been mentioned that the rearranged compounds 35 and 39 exhibited relatively higher HIV inhibitory effect. Most of the synthesized compounds were also found to possess good anti-TMV activity, of which compound 9 showed similar in vivo anti-TMV activity to commercial plant virucide Ribavirin. This work provides a new and efficient approach to evolve novel multi-functional antiviral agents by rational integration and optimization of previously reported antiviral agents.

PYRAZOLE COMPOUNDS

The present invention relates to wherein each symbol is as defined in the specification. The compound has a superior mineralocorticoid receptor antagonistic action and is useful as an agent for the prophylaxis or treatment of a disease or condition mediated by the mineralocorticoid receptor activation.

Antiretroviral hydrazine derivatives

The invention relates to compounds of formula STR1 and salts, pharmaceutical compositions, intermediates and processes of preparation thereof.

Facile Synthesis of Potent HIV-1 Protease Inhibitors containing a Novel Pseudo-symmetric Dipeptide Isostere

A series of potent inhibitors of the HIV-1 protease containing a novel pseudo-symmetric dipeptide isostere 3 was synthesized via ring opening of a protected epoxide with various substituted hydrazines.