149288-99-3

Upstream product

• 120-47-8 Ethyl 4-hydroxybenzoate 
• 2014-83-7 1,3-Dichloro-2-chloromethyl-benzene 

Downstream Products

• 149289-09-8 4-(2,6-dichlorobenzyloxy)benzoic acid 
• 1160250-95-2 4-(2,6-dichlorobenzyloxy)benzoyl chloride 
• 1363621-26-4 ethyl 5-amino-2-(4-(2,6-dichlorobenzyloxy)phenyl)oxazole-4-carboxylate 
• 1363621-27-5 ethyl 5-(4-chlorobenzamido)-2-(4-(2,6-dichlorobenzyloxy)phenyl)oxazole-4-carboxylate 
• 1363621-28-6 5-(4-chlorobenzamido)-2-(4-(2,6-dichlorobenzyloxy)phenyl)oxazole-4-carboxylic acid 
• 1630012-53-1 C₁₅H₁₀Cl₂N₂O₃ 
• 1630012-40-6 C₁₄H₁₂Cl₂N₂O₂ 
• 1630013-21-6 4-butyl-5-(4-(2,6-dichlorobenzyloxy)phenyl)-2H-1,2,4-triazole-3(4H)-one 
• 1630012-75-7 C₁₉H₂₁Cl₂N₃O₃ 

Relevant academic research and scientific papers

Synthesis and anticonvulsant activity evaluation of 4-butyl-5-(4- alkoxyphenyl)-2H-1,2,4-triazole-3(4H)-ones

A series of 4-butyl-5-(4-alkoxyphenyl)-2H-1,2,4-triazole-3(4H)-ones (6a-6u) was designed and synthesized. The anticonvulsant effects and neurotoxicity of the compounds were evaluated with maximal electroshock test and rotarod test. Among the synthetic compounds, 4-butyl-5-(4-(2-fluorinebenzyl)phenyl)-2H-1,2,4- triazole-3 (4H)-one (6k) was the most potent with ED50 value of 27.4 mg/kg and protective index (PI = TD50/ED50) value of 12.0. Besides the anti-MES efficacy, the potency of compound 6k against seizures induced by pentylenetetrazole (PTZ), 3-mercaptopropionic acid (3-MP), and bicuculline (BIC) was also established, which suggested that the mechanisms of action including enhancing of GABAergic activity might be involved in its anticonvulsant activity.

Synthesis and evaluation of anti-tubercular and antibacterial activities of new 4-(2,6-dichlorobenzyloxy)phenyl thiazole, oxazole and imidazole derivatives. Part 2

A series of substituted 4-(2,6-dichlorobenzyloxy)phenyl thiazole, oxazole and imidazole derivatives were synthesized. The derivatives were screened for in vitro anti-tubercular activities against Mycobacterium tuberculosis H37Rv using the Microplate Alamar Blue Assay (MABA), and antibacterial activities with agar dilution method against clinical S. aureus, E. coli, S. pneumoniae and penicilin-resistant S. pneumoniae. Among 15 compounds, several thiazole derivatives exhibited good anti-tubercular activities with MIC values between 1 μM and 61.2 μM, and potent activities against S. pneumoniae with MIC values less than 0.134 μM. These studies suggest that the thiazole scaffold may serve as a new promising template for further elaboration as anti-tubercular and antibacterial drugs.