149296-43-5Relevant academic research and scientific papers
Stereochemistry of Addition of Allylic Grignard Reagents to α,β-Ethylenic Ketones
Zair, Touriya,Santelli-Rouvier, Christiane,Santelli, Maurice
, p. 2686 - 2693 (2007/10/02)
The stereochemistry of the addition of allylic Grignard reagents, (mainly crotylmagnesium chloride) to various conjugated enones has been investigated and a compact transition state is postulated.For s-cis-enones bearing no bulky substituents, a boat transition state, involving a trans-crotylmagnesium chloride, occurs leading to erythro-1,5-hexadien-3-ols as the major or only product.
