149297-79-0Relevant academic research and scientific papers
A NOVEL AND EFFICIENT SYNTHESIS OF ISOGUANOSINE
Chern, Ji-Wang,Lee, Horng-Yuh,Huang, Min,Shish, Fang-Jy
, p. 2151 - 2154 (2007/10/02)
Isoguanosine (4b) was synthesized by a one-pot reaction involving a condensation of 5-amino-1-(β-D-ribofuranosyl)imidazole-4-carboxamide (1b) with benzoyl isothiocyanate, treatment of the resulting thiourea derivative with DCC furnished 5-(N1-benzoylcarbamoyl)aminoimidazole-4-carbonitrile (3b) which was then annulated with ethanolic ammonia to afford isoguanosine in a 68percent yield from 1b.
RING OPENING AND CLOSING REACTIONS OF IMIDAZOLES AND OTHER 1,3-DIAZAHETEROCYCLES WITH VINYL CHLOROFORMATE AND PHENYL CHLOROFORMATE
Pratt, R. F.,Kraus, K. K.
, p. 2431 - 2434 (2007/10/02)
Treatment of imidazole and benzimidazole with vinyl chloroformate or phenyl chloroformate in weakly alkaline aqueous solution leads to their conversion into the corresponding imidazol-2-ones; in weakly acidic solutions these chloroformates convert adenine into isoquanine, 6-methylaminopurine into 1-methylisoquanine and pyrimidine into an acyclic product.
