149301-79-1 Usage
Uses
Arachidonyl trifluoromethyl ketone (AACOCF3) has been used as a anandamide degradation inhibitor to study its effects in primary astrocyte cultures.
Definition
ChEBI: A fatty acid derivative that is arachidonic acid in which the OH part of the carboxy group has been replaced by a trifluoromethyl group
Biological Activity
Inhibitor of cytosolic (85 kDa) phospholipase A 2 . Also inhibits fatty acid amide hydrolase (FAAH, anandamide amidase) in vitro .
Biochem/physiol Actions
Arachidonyl trifluoromethyl ketone (AACOCF3) plays a role in the inhibition of 12-hydroxyeicosatetraenoic acid (12-HETE) and thromboxane B2 produced by the platelets.
references
[1]. ackermann ej, conde-frieboes k, dennis ea. inhibition of macrophage ca(2+)-independent phospholipase a2 by bromoenol lactone and trifluoromethyl ketones. j biol chem, 1995, 270(1): 445-450.[2]. riendeau d, guay j, weech pk, et al. arachidonyl trifluoromethyl ketone, a potent inhibitor of 85-kda phospholipase a2, blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets. j biol chem, 1994, 269(22): 15619-15624.[3]. malaviya r, ansell j, hall l, et al. targeting cytosolic phospholipase a2 by arachidonyl trifluoromethyl ketone prevents chronic inflammation in mice. eur j pharmacol, 2006, 539(3): 195-204.
Check Digit Verification of cas no
The CAS Registry Mumber 149301-79-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,9,3,0 and 1 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 149301-79:
(8*1)+(7*4)+(6*9)+(5*3)+(4*0)+(3*1)+(2*7)+(1*9)=131
131 % 10 = 1
So 149301-79-1 is a valid CAS Registry Number.
InChI:InChI=1/C21H31F3O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(25)21(22,23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3/b7-6-,10-9-,13-12-,16-15-
