149342-28-9

Downstream Products

• 176718-64-2 (3aR,4S,6aS)-benzyl 2,2-dimethyl-4-(trityloxymethyl)tetrahydro-3aH-[1,3]dioxolo[4,5-c]pyrrole-5(4H)carboxylate 
• 153220-80-5 (2R,3S,4R)-N-tert-butoxycarbonyl-3,4-isopropylidenedioxy-5-trityloxymethylpyrrolidine 
• 176718-67-5 (2S,3R,4S)-4-(tert-Butyl-dimethyl-silanyloxy)-3-methoxymethoxy-2-trityloxymethyl-pyrrolidine-1-carboxylic acid benzyl ester 
• 176718-65-3 (2S,3R,4S)-4-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-2-trityloxymethyl-pyrrolidine-1-carboxylic acid benzyl ester 
• 176718-68-6 (2S,3R,4S)-N-benzyloxycarbonyl-4-hydroxy-3-methoxymethyloxy-2-trityloxymethylpyrrolidine 

Relevant academic research and scientific papers

Hydroxylated pyrrolidines. Synthesis of 1,4-dideoxy-1,4-imino-L-lyxitol, 1,4,5-trideoxy-1,4-imino-D- and -L-lyxo-hexitol, 2,3,6-trideoxy-3,6-imino-D-glycero-L-altro- and -D-glycero-L-galacto-octitols, and of a chiral potential precursor of carbapenem systems

Enantiospecific syntheses are reported for the title pyrrolidines, from carbohydrate precursors. An intermediate in one of the routes, ethyl 2,3,6-trideoxy-3,6-imino-4,5:7,8-di-O-isopropylidene-D-glycero-L-altro-octonate (23), could be converted in two steps into a β-lactam.

Synthesis of 1,4-imino-L-lyxitols modified at C-5 and their evaluation as inhibitors of GH38 α-mannosidases

A synthetic approach to 1,4-imino-L-lyxitols with various modifications at the C-5 position is reported. These imino-L-lyxitol cores were used for the preparation of a series of N-(4-halobenzyl)polyhydroxypyrrolidines. An impact of the C-5 modification on