1493792-70-3Relevant academic research and scientific papers
An efficient synthesis of Nα-protected amino and peptide acid aryl amides via iodine-mediated oxidative acylation of N α-protected amino and peptide thioacids
Madhu, Chilakapati,Vishwanatha,Sureshbabu, Vommina V.
, p. 2727 - 2736 (2013/10/21)
Thioacids derived from N-protected amino or dipeptide and tripeptide acids undergo facile N-acylation with aromatic amines to afford N-protected amino or peptide aryl amides in good to excellent yields and enantiopurities. The method also furnishes difficult-to-prepare N-Fmoc amino acid 4-nitroanilides in good yields. This simple oxidative Nα-acylation of thioacids with aromatic amines proceeds in the presence of iodine, 1-hydroxybenzotriazole and N,N-diisopropylethylamine at room temperature in tetrahydrofuran. Georg Thieme Verlag Stuttgart New York.
