149398-34-5

Usage

Chemical structure

A piperidine derivative with a cyclohexylmethyl group attached to the nitrogen atom

Applications

a. Intermediate in the synthesis of pharmaceuticals and other organic compounds
b. Medicinal chemistry and drug development
c. Research and development due to unique chemical properties and reactivity
d. Potential therapeutic effects and biological activity

Versatility

Wide range of potential applications in various fields

Importance

Considered an important chemical compound due to its diverse applications and properties

Upstream product

• 5382-16-1 4-HYDROXYPIPERIDINE 
• 2550-36-9 Cyclohexylmethyl bromide 

Relevant academic research and scientific papers

Design and synthesis of new bifunctional sigma-1 selective ligands with antioxidant activity

Herein we report the synthesis of new bifunctional sigma-1 (σ1)-selective ligands with antioxidant activity. To achieve this goal, we combined the structure of lipoic acid, a universal antioxidant, with an appropriate sigma aminic moiety. Ligands 14 and 26 displayed high affinity and selectivity for σ1 receptors (K iσ1 = 1.8 and 5.5 nM; Kiσ 2/σ1 = 354 and 414, respectively). Compound 26 exhibited in vivo antiopioid effects on kappa opioid (KOP) receptor-mediated analgesia. In rat liver and brain mitochondria (RLM, RBM), this compound significantly reduced the swelling and the oxidation of thiol groups induced by calcium ions. Our results demonstrate that the tested compound has protective effects against oxidative stress.