14940-65-9Relevant academic research and scientific papers
Synthesis of 1-Hydrogermatrane Labelled with Tritium on the Ge–H Bond
Avrorin,Kochina,Ignat’ev,Ermolenko, Yu. Е.
, p. 2230 - 2232 (2018)
The method of preparation of 1Н-germatrane labelled with tritium on the germanium–hydrogen bond was elaborated with specific activity of 0.3 mCi/mg (~70 mCi/mmol).
Ozone Production in the Reaction of T2 and O2 Gas: A Comparison of Experimental Results and Model Predictions
Failor, R. A.,Souers, P. C.,Magnotta, F.
, p. 3742 - 3752 (1992)
Ozone, predicted to be an important intermediate species in T2 oxidation, was monitored in situ by UV absorption spectroscopy for 0.01 - 1.0 mol percent T2 in O2 (1 atm, 298 K).These are the first measurements of a tritium oxidation reaction intermediate.The experimental results were compared with the predictions of our comprehensive model of tritium oxidations The experimentally determined temporal variation in ozone concentration is qualitatively reproduced by the model.As predicted, the measured initial rate of ozone production varied linearly with the initial T2 concentration (0), but with a value one-third of that predicted.The steady-state ozone concentration (SS) was predicted to be dependent on 00.3, but measured values showed a 00.6 dependence, resulting in SS a factor of 4 larger than predicted for a 1.0percent T2-O2 mixture.Addition of H2 to the T2-O2 mixture, to differentiate between the radiolytic and chemical behavior of the tritium, produced a decrease in SS which was larger than predicted.Changing the reaction cell surface-to-volume ratio showed indications of minor surface removal of ozone.No resonable variation in model input parameters brought both the predicted initial ozone production rates and steady-state concentrations of ozone into agreement with the experimental results.Though qualitative agreement was achieved, further studies, with emphasis on surface effects, are necessary to explain quantitative differences and gain a greater understanding of the oxidation mechanism.
Photoredox-catalyzed deuteration and tritiation of pharmaceutical compounds
Loh, Yong Yao,Nagao, Kazunori,Hoover, Andrew J.,Hesk, David,Rivera, Nelo R.,Colletti, Steven L.,Davies, Ian W.,MacMillan, David W. C.
, p. 1182 - 1187 (2017/12/08)
Deuterium- and tritium-labeled pharmaceutical compounds are pivotal diagnostic tools in drug discovery research, providing vital information about the biological fate of drugs and drug metabolites. Herein we demonstrate that a photoredox-mediated hydrogen
