149402-51-7 Usage
Description
HPPH is a chlorin that acts as a photosensitizer in photodynamic therapy (PDT) when stimulated with light at 655 nm. When administered systemically, HPPH accumulates in tumor cells and, when stimulated with light in the presence of oxygen, reactive oxygen species (ROS) are generated, leading to necrosis within the tumor. HPPH, at a dose of 0.5 mg/kg, increases survival in a nude rat model of glioma. It works synergistically with gemcitabine in several pancreatic cancer cell lines to induce cell death.
Uses
Photochlor is an anticancer photodynamic therapy drug that triggers multiple drug release and tumor killing cells in mouse breast cancer xenograft. Also functions as a photochlor-mediated photodynamic therapy for non-small cellular lung cancer treatment in murine model.
Check Digit Verification of cas no
The CAS Registry Mumber 149402-51-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,9,4,0 and 2 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 149402-51:
(8*1)+(7*4)+(6*9)+(5*4)+(4*0)+(3*2)+(2*5)+(1*1)=127
127 % 10 = 7
So 149402-51-7 is a valid CAS Registry Number.
InChI:InChI=1/C39H48N4O4/c1-8-10-11-12-15-47-24(7)36-22(5)30-17-29-21(4)26(13-14-35(45)46)38(42-29)27-16-34(44)37-23(6)31(43-39(27)37)18-32-25(9-2)20(3)28(40-32)19-33(36)41-30/h17-19,21,24,26,40-41H,8-16H2,1-7H3,(H,45,46)/b28-19-,29-17-,30-17-,31-18-,32-18-,33-19-,38-27-/t21-,24?,26-/m0/s1