14943-94-3

Basic information

• Product Name: 2-(2-aminoethylthio)benzoic acid
• Synonyms: 2-(2-aminoethylthio)benzoic acid;Nsc173136;2-(2-aminoethylthio)benzoic acid hcl;2-[(2-aminoethyl)thio]benzoic acid hydrochloride
• CAS NO: 14943-94-3
• Molecular Formula: C9H11 N O2 S . Cl H
• Molecular Weight: 0
• Mol File: 14943-94-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 357.3°Cat760mmHg
• Flash Point: 169.9°C
• Appearance: /
• Density: 1.3g/cm³
• Vapor Pressure: 1E-05mmHg at 25°C
• Refractive Index: 1.63
• CAS DataBase Reference: 2-(2-aminoethylthio)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-aminoethylthio)benzoic acid(14943-94-3)
• EPA Substance Registry System: 2-(2-aminoethylthio)benzoic acid(14943-94-3)

Safety Data

• Hazardous Substances Data: 14943-94-3(Hazardous Substances Data)

Usage

Uses

2-[(2-Aminoethyl)thio]benzoic acid hydrochloride is used as a reactant in the preparation of benzo condensed heterocycles with 7-?membered rings.

Synthesis Reference(s)

The Journal of Organic Chemistry, 54, p. 653, 1989 DOI: 10.1021/jo00264a028

InChI:InChI=1/C9H11NO2S/c10-5-6-13-8-4-2-1-3-7(8)9(11)12/h1-4H,5-6,10H2,(H,11,12)

Upstream product

• 151-56-4 ethyleneimine 
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Relevant articles and documents

2-(Arylthio)ethanamines and &α-(Arylthio)propionamides with Antidepressant Activity

Reaction of aziridine with thiophenols affords 2-arylthioethanamines; with 2-methylaziridine, ring opening occurs regiospecifically to provide 1-arylthio-2-propanamines.The structure of one member of this group, 1-(4-chlorophenylthio)-2-propanamine (7), has been proved by other unambiguous syntheses. 7 and isomer 12 arise from the alkylation of 4-chlorothiophenol with 2-chloropropylamine as well as from the displacement of the tosyl group in 1-(4-chlorophenylthio)-2-tosyloxypropane (13).Alkylation of 4-chlorothiophenol with α-chloropropionamide affords 11 which leads to 12 on LAH reduction.Ethanamines and propanamines are converted into guanidines, amides, ureas and thioureas.Many arylthioethanamines, e.g. 7, 22, 28, 38 and 39 (as HCl salts) and α-arylthiopropionamides, e.g. 11, 86, 91, 93 and 96 exhibit good activity in the DOPA potentiation and reserpine antagonism tests.Among these, 7 HCl is the most potent and does not inhibit rat brain MAO activity.In clinical trials, C 2998-Go compares favourably with imipramine.