149438-16-4

Basic information

• Product Name: 2,5-diamino-4-hydroxy-6-(2'-deoxyribosyl)-formamidopyrimidine
• Synonyms: 2,5-diamino-4-hydroxy-6-(2'-deoxyribosyl)-formamidopyrimidine
• CAS NO: 149438-16-4
• Molecular Formula: C10H15N5O5
• Molecular Weight: 285.2566
• Mol File: 149438-16-4.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 582.7°Cat760mmHg
• Flash Point: 306.2°C
• Appearance: /
• Density: 1.95g/cm³
• PKA: 7.78±0.50(Predicted)
• CAS DataBase Reference: 2,5-diamino-4-hydroxy-6-(2'-deoxyribosyl)-formamidopyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-diamino-4-hydroxy-6-(2'-deoxyribosyl)-formamidopyrimidine(149438-16-4)
• EPA Substance Registry System: 2,5-diamino-4-hydroxy-6-(2'-deoxyribosyl)-formamidopyrimidine(149438-16-4)

Safety Data

• Hazardous Substances Data: 149438-16-4(Hazardous Substances Data)

Usage

Molecular weight

267.27 g/mol

Structure

A formamidopyrimidine ring with a 2'-deoxyribose sugar moiety, containing two amino groups at the 2 and 5 positions, a hydroxyl group at the 4 position, and a formamido group at the 6 position.

Formation

Fapy-dA is formed by the oxidation of guanine in DNA, which can be caused by reactive oxygen species, ionizing radiation, and chemical carcinogens.

Classification

It is an oxidized derivative of 2'-deoxyadenosine.

Biological role

Fapy-dA is involved in the repair of DNA damage and has been linked to the development of various human diseases, including cancer and neurodegenerative disorders.

Research significance

Fapy-dA has been studied for its potential use as a biomarker for oxidative stress and DNA damage, and it is an important target for understanding the mechanisms of DNA damage and repair.