14945-74-5Relevant articles and documents
Novel synthesis of pyrrolo[2,1-a]-isoquinoline using the reaction of isoquinolinium salts with active methylene compounds
Fujita, Reiko,Watanabe, Noriyuki,Tomisawa, Hiroshi
, p. 435 - 438 (2007/10/03)
2-Alkyl-1-methylthioisoquinolinium salts were easily prepared from 2-alkyl-1(2H)-isoquinolones via 2-alkyl-1(2H)-thioisoquinolones in two steps. Under mild conditions, the reaction of 2-alkyl-1-methylthioisoquinolinium salts with active methylene compounds in the presence of sodium hydride afforded 2-alkyl-1-(substituted methylene)isoquinolines in good yields. The cyclizationof 2-benzylisoquinolines using acetic anhydride produced the pyrrolo[2,1-a]isoquinolines. Further, the reaction of 1-chloro-2-phenacylisoquinolinium salt with active methylene compounds afforded the pyrrolo[2,1-a]isoquinolines in one pot.
