149457-46-5

Basic information

• Product Name: Benzene, 1-bromo-4-methoxy-2-[(4-methoxyphenyl)ethynyl]-
• CAS NO: 149457-46-5
• Molecular Formula: C16H13BrO2
• Molecular Weight: 317.182
• Mol File: 149457-46-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzene, 1-bromo-4-methoxy-2-[(4-methoxyphenyl)ethynyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-bromo-4-methoxy-2-[(4-methoxyphenyl)ethynyl]-(149457-46-5)
• EPA Substance Registry System: Benzene, 1-bromo-4-methoxy-2-[(4-methoxyphenyl)ethynyl]-(149457-46-5)

Safety Data

• Hazardous Substances Data: 149457-46-5(Hazardous Substances Data)

Upstream product

• 766-85-8 3-methoxy-1-iodobenzene 
• 149457-43-2 1-Bromo-4-methoxy-2-[(E)-2-(4-methoxy-phenyl)-vinyl]-benzene 
• 4897-68-1 2-iodo-4-methoxybromobenzene 
• 768-60-5 4-methoxyphenylacetylen 

Downstream Products

• 1163701-64-1 C₂₇H₂₆O₄S 
• 1314774-97-4 C₂₆H₂₇NO₃S 
• 1314774-93-0 C₂₆H₂₅NO₄S 
• 1314774-92-9 C₂₈H₂₉NO₄S 
• 1261352-32-2 5-methoxy-2-(4-methoxyphenyl)-3-{4-[ 2-(1-piperidinyl)ethoxy]phenyl}benzo[b]thiophene 
• 1135317-03-1 3-(4-hydroxyphenyl)-5-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene 
• 1163701-04-9 4-methoxy-2-[ (4-methoxyphenyl)ethynyl]thioanisole 
• 141240-84-8 5-Methoxy-2-(4-methoxy-phenyl)-1,1-diphenyl-1H-benzo[b]silole 
• 141240-79-1 [4-Methoxy-2-(4-methoxy-phenylethynyl)-phenyl]-diphenyl-silane 

Relevant articles and documents

Parallel synthesis of a desketoraloxifene analogue library via iodocyclization/palladium-catalyzed coupling

For a future structure-activity relationship (SAR) study, a library of desketoraloxifene analogues has been prepared by parallel synthesis using iodocyclization and subsequent palladium-catalyzed coupling reactions. Points of desketoraloxifene diversification involve the two phenolic hydroxyl groups and the aliphatic amine side chain. This approach affords oxygen-bearing 3-iodobenzo[b]thiophenes 4 in excellent yields, which are easily further elaborated using a two-step approach involving Suzuki-Miyaura and Mitsunobu coupling reactions to give multimethoxy-substituted desketoraloxifene analogues 6. Various hydroxyl-substituted desketoraloxifene analogues 7 were subsequently generated by demethylation with BBr3.

A general and simple synthesis of phosphindoles

A first simple and general synthesis of phosphindoles by intramolecular cyclisation of secondary o-phosphinotolanes is described.