149457-46-5

Upstream product

• 4897-68-1 2-iodo-4-methoxybromobenzene 
• 768-60-5 4-methoxyphenylacetylen 
• 149457-43-2 1-Bromo-4-methoxy-2-[(E)-2-(4-methoxy-phenyl)-vinyl]-benzene 
• 766-85-8 3-methoxy-1-iodobenzene 

Downstream Products

• 141240-84-8 5-Methoxy-2-(4-methoxy-phenyl)-1,1-diphenyl-1H-benzo[b]silole 
• 1163701-04-9 4-methoxy-2-[ (4-methoxyphenyl)ethynyl]thioanisole 
• 1135317-03-1 3-(4-hydroxyphenyl)-5-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene 
• 1261352-32-2 5-methoxy-2-(4-methoxyphenyl)-3-{4-[ 2-(1-piperidinyl)ethoxy]phenyl}benzo[b]thiophene 
• 1314774-92-9 C₂₈H₂₉NO₄S 
• 1314774-93-0 C₂₆H₂₅NO₄S 
• 1314774-97-4 C₂₆H₂₇NO₃S 
• 1163701-64-1 C₂₇H₂₆O₄S 
• 141240-79-1 [4-Methoxy-2-(4-methoxy-phenylethynyl)-phenyl]-diphenyl-silane 

Relevant academic research and scientific papers

Parallel synthesis of a desketoraloxifene analogue library via iodocyclization/palladium-catalyzed coupling

For a future structure-activity relationship (SAR) study, a library of desketoraloxifene analogues has been prepared by parallel synthesis using iodocyclization and subsequent palladium-catalyzed coupling reactions. Points of desketoraloxifene diversification involve the two phenolic hydroxyl groups and the aliphatic amine side chain. This approach affords oxygen-bearing 3-iodobenzo[b]thiophenes 4 in excellent yields, which are easily further elaborated using a two-step approach involving Suzuki-Miyaura and Mitsunobu coupling reactions to give multimethoxy-substituted desketoraloxifene analogues 6. Various hydroxyl-substituted desketoraloxifene analogues 7 were subsequently generated by demethylation with BBr3.

A novel palladium-mediated coupling approach to 2,3-disubstituted benzo[b]thiophenes and its application to the synthesis of tubulin binding agents

Flexible, convergent access to 2,3-disubstituted benzo[b]thiophenes has been developed. The most concise approach involves sequential coupling of o-bromoiodobenzenes with benzylmercaptan and zinc acetylides to give benzyl o-ethynylpnenyl sulfides which re

A general and simple synthesis of phosphindoles

A first simple and general synthesis of phosphindoles by intramolecular cyclisation of secondary o-phosphinotolanes is described.