14948-94-8 Usage
Uses
Used in Pharmaceutical Industry:
2-Naphthalenecarboxamidine hydrochloride is used as a probing inhibitor for its ability to bind to human urokinase crystals. This application is significant in the study and development of targeted therapies for various diseases, as it helps researchers understand the interactions between the compound and its biological targets.
Used in Research and Development:
In the field of research and development, 2-naphthalenecarboxamidine hydrochloride serves as a valuable tool for studying the structure and function of proteins, particularly those involved in enzymatic reactions. Its use as a probing inhibitor allows scientists to gain insights into the mechanisms of action and potential therapeutic applications of 2-naphthalenecarboxamidine hydrochloride.
Used in Drug Design and Development:
The unique chemical properties of 2-naphthalenecarboxamidine hydrochloride make it a promising candidate for drug design and development. Its ability to interact with specific biological targets, such as human urokinase, can be leveraged to create novel therapeutic agents for the treatment of various diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 14948-94-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,9,4 and 8 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 14948-94:
(7*1)+(6*4)+(5*9)+(4*4)+(3*8)+(2*9)+(1*4)=138
138 % 10 = 8
So 14948-94-8 is a valid CAS Registry Number.
14948-94-8Relevant academic research and scientific papers
Facile synthesis of 3,5-diaryl-1,2,4-triazoles via copper-catalyzed domino nucleophilic substitution/oxidative cyclization using amidines or imidates as substrates
Sudheendran, Kavitha,Schmidt, Dietmar,Frey, Wolfgang,Conrad, Jürgen,Beifuss, Uwe
, p. 1635 - 1645 (2014/02/14)
Two methods for the synthesis of 3,5-diaryl-1,2,4-triazoles, both domino reactions, are reported. The first procedure, the Cu(OTf)2-catalyzed reaction between two amidines using NaHCO3 as a base, 1,10-phenanthroline as an additive and K3[Fe(CN)6]/ atmospheric oxygen as the oxidant, delivers 3,5-diaryl-1,2,4-triazoles with yields up to 68%. The second procedure for the synthesis of 3,5-diaryl-1,2,4- triazoles with yields up to 64% rests on the Cu(OTf)2-catalyzed reaction between two imidates and ammonium carbonate. This method features the formation of three bonds in a single synthetic step.
