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149506-16-1

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149506-16-1 Usage

General Description

3-(4-Bromophenyl)cyclobutane-1-carboxylic acid is an organic chemical compound with the molecular formula C11H11BrO2. It is a carboxylic acid derivative that contains a cyclobutane ring and a bromo-substituted phenyl group. 3-(4-BROMOPHENYL)CYCLOBUTANE-1-CARBOXYLIC ACID is used in pharmaceutical research and drug development for its potential biological and medicinal properties. It has been studied for its potential as an anti-inflammatory and analgesic agent, as well as for its potential in treating various medical conditions. Additionally, it may have applications in other fields such as materials science and organic synthesis due to its unique molecular structure and properties.

Check Digit Verification of cas no

The CAS Registry Mumber 149506-16-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,9,5,0 and 6 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 149506-16:
(8*1)+(7*4)+(6*9)+(5*5)+(4*0)+(3*6)+(2*1)+(1*6)=141
141 % 10 = 1
So 149506-16-1 is a valid CAS Registry Number.

149506-16-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-(4-bromophenyl)cyclobutane-1-carboxylic acid

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:149506-16-1 SDS

149506-16-1Downstream Products

149506-16-1Relevant articles and documents

Structure-based design of tricyclic NF-κB inducing kinase (NIK) inhibitors that have high selectivity over phosphoinositide-3-kinase (PI3K)

Castanedo, Georgette M.,Blaquiere, Nicole,Beresini, Maureen,Bravo, Brandon,Brightbill, Hans,Chen, Jacob,Cui, Hai-Feng,Eigenbrot, Charles,Everett, Christine,Feng, Jianwen,Godemann, Robert,Gogol, Emily,Hymowitz, Sarah,Johnson, Adam,Kayagaki, Nobuhiko,Kohli, Pawan Bir,Knüppel, Kathleen,Kraemer, Joachim,Krüger, Susan,Loke, Pui,McEwan, Paul,Montalbetti, Christian,Roberts, David A.,Smith, Myron,Steinbacher, Stefan,Sujatha-Bhaskar, Swathi,Takahashi, Ryan,Wang, Xiaolu,Wu, Lawren C.,Zhang, Yamin,Staben, Steven T.

, p. 627 - 640 (2017/02/05)

We report here structure-guided optimization of a novel series of NF-κB inducing kinase (NIK) inhibitors. Starting from a modestly potent, low molecular weight lead, activity was improved by designing a type 11/2 binding mode that accessed a back pocket past the methionine-471 gatekeeper. Divergent binding modes in NIK and PI3K were exploited to dampen PI3K inhibition while maintaining NIK inhibition within these series. Potent compounds were discovered that selectively inhibit the nuclear translocation of NF-κB2 (p52/REL-B) but not canonical NF-κB1 (REL-A/p50).

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