149506-24-1

Basic information

• Product Name: METHYL 3'-NITRO[1,1'-BIPHENYL]-3-CARBOXYLATE
• Synonyms: METHYL 3'-NITRO[1,1'-BIPHENYL]-3-CARBOXYLATE;AKOS BAR-1973;Methyl 3-(3-nitrophenyl)benzoate
• CAS NO: 149506-24-1
• Molecular Formula: C₁₄H₁₁NO₄
• Molecular Weight: 257.24
• Mol File: 149506-24-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: 88-90 °C
• Boiling Point: 420.2±38.0 °C(Predicted)
• Appearance: /
• Density: 1.258±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: METHYL 3'-NITRO[1,1'-BIPHENYL]-3-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 3'-NITRO[1,1'-BIPHENYL]-3-CARBOXYLATE(149506-24-1)
• EPA Substance Registry System: METHYL 3'-NITRO[1,1'-BIPHENYL]-3-CARBOXYLATE(149506-24-1)

Safety Data

• Hazardous Substances Data: 149506-24-1(Hazardous Substances Data)

Usage

Uses

Methyl 3-(3-Nitrophenyl)benzoate is a useful intermediate for organic synthesis and other chemical processes.

Upstream product

• 618-89-3 methyl 3-bromobenzoate 
• 13331-27-6 m-nitrobenzene boronic acid 
• 585-79-5 m-nitrobromobenzene 
• 99769-19-4 [3-(methoxycarbonyl)phenyl]boronic acid 

Relevant articles and documents

Design and synthesis of short amphiphilic cationic peptidomimetics based on biphenyl backbone as antibacterial agents

Antimicrobial peptides (AMPs) and their synthetic mimics have received recent interest as new alternatives to traditional antibiotics in attempts to overcome the rise of antibiotic resistance in many microbes. AMPs are part of the natural defenses of most living organisms and they also have a unique mechanism of action against bacteria. Herein, a new series of short amphiphilic cationic peptidomimetics were synthesized by incorporating the 3′-amino-[1,1′-biphenyl]-3-carboxylic acid backbone to mimic the essential properties of natural AMPs. By altering hydrophobicity and charge, we identified the most potent analogue 25g that was active against both Gram-positive Staphylococcus aureus (MIC = 15.6 μM) and Gram-negative Escherichia coli (MIC = 7.8 μM) bacteria. Cytoplasmic permeability assay results revealed that 25g acts primarily by depolarization of lipids in cytoplasmic membranes. The active compounds were also investigated for their cytotoxicity to human cells, lysis of lipid bilayers using tethered bilayer lipid membranes (tBLMs) and their activity against established biofilms of S. aureus and E. coli.

HEPATITIS B CORE PROTEIN ALLOSTERIC MODULATORS

ABSTRACT The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

Biarylaniline phenethanolamines as potent and selective β3 adrenergic receptor agonists

The synthesis of a series of phenethanolamine aniline agonists that contain an aniline ring on the right-hand side of the molecule substituted at the meta position with a benzoic acid or a pyridyl carboxylate is described. Several of the analogues (e.g.,