149506-57-0

Basic information

• Product Name: 3-[(4-methoxyphenyl)sulfanyl]benzonitrile
• Synonyms: 3-[(4-Methoxyphenyl)sulfanyl]benzonitrile; benzonitrile, 3-[(4-methoxyphenyl)thio]-
• CAS NO: 149506-57-0
• Molecular Formula: C₁₄H₁₁NOS
• Molecular Weight: 241.3082
• Mol File: 149506-57-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 412.7°C at 760 mmHg
• Flash Point: 203.4°C
• Density: 1.22g/cm³
• Vapor Pressure: 5.09E-07mmHg at 25°C
• Refractive Index: 1.635
• CAS DataBase Reference: 3-[(4-methoxyphenyl)sulfanyl]benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[(4-methoxyphenyl)sulfanyl]benzonitrile(149506-57-0)
• EPA Substance Registry System: 3-[(4-methoxyphenyl)sulfanyl]benzonitrile(149506-57-0)

Safety Data

• Hazardous Substances Data: 149506-57-0(Hazardous Substances Data)

Upstream product

• 6952-59-6 3-cyanobromobenzene 
• 696-62-8 para-iodoanisole 
• 51124-45-9 4-amino-3-cyano-4'-methoxy-diphenylsulphide 
• 696-63-9 4-Methoxybenzenethiol 
• 403-54-3 m-Fluorobenzonitrile 
• 5335-87-5 4,4'-dimethoxyphenyl disulfide 

Relevant articles and documents

SINGLE-STEP SYNTHESIS METHOD OF ARYL THIOL AND APPLICATION THEREOF

The present invention relates to a single-step synthesis method of aryl thiol, and more specifically, to a method of synthesizing aryl thiol in a single-step by making aryl halide react with alkane dithiol in the presence of a transition metal catalyst. According to the present invention, a single-step synthesis method using the transition metal catalyst, the synthesis method which is capable of synthesizing aryl thiol from aryl halide at a high yield, can be provided. Various aryl halides may be applied to the synthesis method. Further, the synthesis method has advantages that an easily usable reagent may be used, operations are simple, and reactions can be performed under mild conditions. In addition, the synthesized aryl thiol may be used in the synthesis of advanced molecules such as diaryl sulfides and benzothiophenes.COPYRIGHT KIPO 2017

Iridium and phosphine promoted C-F bond activation: The C-S cross-coupling of aryl fluorides with diaryl disulfides to synthesize thioethers

Carbon-fluorine bond is the strongest known single bond to carbon and proved very difficult to cleave. An iridium and phosphine promoted C-F bond activation was developed, for the first time achieving the C-S cross-coupling reaction of disulfides with aryl fluorides using iridium complex. The corresponding monoarylthiolation products were obtained at moderate to good yields. Thus, it represents a new method for the synthesis of aryl sulfides through C-F bond activation.

Synthesis of diaryl ethers, diaryl thioethers, and diarylamines mediated by potassium fluoride-alumina and 18-crown-6: Expansion of scope and utility

An efficient alternative to the Ullmann ether synthesis of diaryl ethers, diaryl thioethers, and diarylamines involving the S(N)Ar addition of a phenol, thiophenol, or aniline to an appropriate aryl halide, mediated by potassium-fluoride alumina and 18-crown-6 in acetonitrile or DMSO, is described. Expansion of the reaction conditions to include DMSO as solvent has resulted in a far greater range of substitution patterns permitted on the electrophile. For example, it was found that electronically unfavorable 3- chlorobenzonitrile could be condensed with 3-methoxyphenol to form the corresponding diaryl ether in 66% yield, a combination not normally amenable to Ullmann coupling. Electron-withdrawing groups present on the electrophile may be as diverse as nitro, cyano, formyl, acetyl, ester, amide, and even aryl. The method features a simple reaction procedure that provides products in generally good to excellent purified yields.