149521-97-1Relevant articles and documents
Small organic molecule catalyzed enantioselective direct aldol reaction in water
Chimni, Swapandeep Singh,Mahajan, Dinesh
, p. 2108 - 2119 (2006)
Protonated pyrrolidine based small organic molecules have been designed and evaluated for the asymmetric direct aldol reaction in water. The designed organocatalysts are multifunctional in nature and exploit the combined effect of hydrogen bonding and hydrophobic interactions for enantioselective catalysis in water. As a result a unique direct asymmetric aldol reaction in water catalyzed by a small organic molecule having an amide linkage has been developed. The developed catalyst affords chiral β-hydroxyketones in good yields (93%) and enantioselectivities (upto 62%) in water.
Design of highly enantioselective organocatalysts based on molecular recognition
Tang, Zhuo,Cun, Lin-Feng,Cui, Xin,Mi, Ai-Qiao,Jiang, Yao-Zhong,Gong, Liu-Zhu
, p. 1263 - 1266 (2006)
Various organocatalysts have been designed based on molecular recognition to catalyze the asymmetric direct aldol reaction of ketones with aryl and alkyl α-keto acids, affording β-hydroxyl carboxylic acids with a tertiary stereogenic center with excellent
Dynamic assembly of a zinc-templated bifunctional organocatalyst in the presence of water for the asymmetric aldol reaction
Serra-Pont, Anna,Alfonso, Ignacio,Jimeno, Ciril,Solà, Jordi
supporting information, p. 17386 - 17389 (2015/12/08)
A bifunctional organocatalytic system consisting of simple pyridine ligands containing separate catalytic functionalities was assembled using ZnCl2. This novel metal-templated catalyst furnished high yields and stereoselectivities towards the a