14954-35-9Relevant academic research and scientific papers
Novel Thiazole Derivatives of Medicinal Potential: Synthesis and Modeling
Abdel-Sattar, Nour E. A.,El-Naggar, Abeer M.,Abdel-Mottaleb
, (2017/08/18)
This paper reports on the synthesis of new thiazole derivatives that could be profitably exploited in medical treatment of tumors. Molecular electronic structures have been modeled within density function theory (DFT) framework. Reactivity indices obtained from the frontier orbital energies as well as electrostatic potential energy maps are discussed and correlated with the molecular structure. X-ray crystallographic data of one of the new compounds is measured and used to support and verify the theoretical results.
Selenium-catalyzed carbonylation of 2-aminothiazole with nitro aromatics to N-aryl-N′-2-thiazolylureas
Zhang, Xiaopeng,Tang, Zhaojing,Niu, Xueli,Li, Zhengwei,Fan, Xuesen,Zhang, Guisheng
supporting information, p. 5266 - 5270 (2016/11/11)
An efficient, economical, and phosgene-free procedure for the synthesis of N-aryl-N′-2-thiazolylureas is reported. With cheap and recyclable nonmetal selenium instead of noble metals as the catalyst, carbon monoxide instead of virulent phosgene as the carbonylation agent, the selenium-catalyzed carbonylation reaction of 2-aminothiazole can proceed smoothly in one-pot manner with a variety of nitro aromatics in the presence of triethylamine to afford the desired N-aryl-N′-2-thiazolylureas mostly in moderate to good yields. Selenium catalyst can be easily recovered due to its phase-transfer catalytic ability and reused without any significant degradation of its catalytic performance.
GUANIDINE COMPOUNDS AND USE THEREOF
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Paragraph 0170; 0171; 0172; 0173; 0174; 0175; 0176, (2017/01/02)
The present invention relates to guanidine compounds and use thereof, and more specifically, to a guanidine derivative having an excellent effect on suppressing cancer-cell proliferation, and suppressing cancer metastasis and recurrence, a method for prep
GUANIDINE COMPOUNDS AND USE THEREOF
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Page/Page column 108; 111, (2015/11/09)
The present invention relates to guanidine compounds for inhibiting mitochondrial oxidative phosphorylation (OXPHOS) and use thereof. More specifically, the present invention relates to a pharmaceutical composition for preventing or treating a OXPHOS-related disease, particularly cancer by inhibiting mitochondrial oxidative phosphorylation and reprogramming cellular metabolism.
TYPE III SECRETION INHIBITORS, ANALOGS AND USES THEREOF
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Page/Page column 88-89, (2009/12/27)
The invention, in some aspects, relates to compounds and compositions useful for inhibiting Type III secretion systems in pathogenic bacteria, such as Yersinia Pestis. In some aspects, the invention relates to methods for discovering inhibitors of the Typ
Synthesis of new unsymmetrical 4,5-dihydroxy-2-imidazolidinones. Dynamic NMR spectroscopic study of the prototropic tautomerism in 1-(2-benzimidazolyl)- 3-phenyl-4,5-dihydroxy-2-imidazolidinone
Ghandi, Mehdi,Olyaei, Abolfazl,Salimi, Farshid
, p. 768 - 775 (2007/10/03)
The acid-catalyzed cyclocondensation in refluxing acetonitrile of aqueous glyoxal with N-heteroaryl-N′-phenylureas 4a-f (heteroaryl = 2-thiazolyl, 2-pyrimidinyl, 2-pyrazinyl, 2-pyridinyl, 3-pyridinyl and 2-benzimidazolyl) led to the formation of the corre
Thiazole, imidazole and oxazole compounds and treatments of disorders associated with protein aging
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, (2008/06/13)
Provided are, among other things, compounds of formula I or IA, . Also provided are methods of treatment with such compounds.
Method for treating glaucoma IIB
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, (2008/06/13)
Provided is a method of decreasing intraocular pressure or improving ocular accommodation in an animal, including a human, comprising administering an intraocular pressure decreasing amount or ocular accommodation improving amount of a compound of the formula I or IA, wherein J is oxygen, sulfur, or N—Rd.
Study of structural parameters related to anthelminthic activity of thiazole derivatives
Walchshofer,Minjat,Tinland,et al.
, p. 59 - 64 (2007/10/02)
Thiazole derivatives were synthesized and their anthelminthic activity was tested against a nematode and cestode. The effect of electronic parameters, lipophilicity and biotransformation on activity is discussed.
