149563-21-3

Basic information

• Product Name: FMOC-(3S,6S,9R)-2-OXO-3-AMINO-7-THIA-1-AZABICYCLO[4.3.0]NONANE-9-CARBOXYLIC ACID
• Synonyms: FMOC-(3S,6S,9R)-2-OXO-3-AMINO-7-THIA-1-AZABICYCLO[4.3.0]NONANE-9-CARBOXYLIC ACID;FMOC-BTD-OH;(3R,6S,8aS)-6-(((9H-fluoren-9-yl)methoxy)carbonylamino)-5-oxohexahydro-2H-thiazolo[3,2-a]pyridine-3-carboxylic acid
• CAS NO: 149563-21-3
• Molecular Formula: C₂₃H₂₂N₂O₅S
• Molecular Weight: 438.5
• Mol File: 149563-21-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 737.1±60.0 °C(Predicted)
• Appearance: /
• Density: 1.47±0.1 g/cm3(Predicted)
• PKA: 3.17±0.40(Predicted)
• CAS DataBase Reference: FMOC-(3S,6S,9R)-2-OXO-3-AMINO-7-THIA-1-AZABICYCLO[4.3.0]NONANE-9-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-(3S,6S,9R)-2-OXO-3-AMINO-7-THIA-1-AZABICYCLO[4.3.0]NONANE-9-CARBOXYLIC ACID(149563-21-3)
• EPA Substance Registry System: FMOC-(3S,6S,9R)-2-OXO-3-AMINO-7-THIA-1-AZABICYCLO[4.3.0]NONANE-9-CARBOXYLIC ACID(149563-21-3)

Safety Data

• Hazardous Substances Data: 149563-21-3(Hazardous Substances Data)

Usage

Uses

Fmoc-(3s,6s,9r)-2-oxo-3-amino-7-thia-1-azabicyclo[4.3.0]nonane-9-carboxylic acid is an intermediate used in the synthesis of cyclic hexapeptides and chimeric peptides as mimics of tendamistat.

Upstream product

• 82263-17-0 γ-Thiophenyl N-phthalyl-L-glutamate 
• 25830-77-7 N-phthaloyl-L-glutamic anhydride 
• 96661-89-1 α-Methyl, γ-thiophenyl N-phthalyl-L-glutamate 
• 96661-90-4 α-Methyl N-phthalyl-L-glutamate γ-carbinol 
• 77603-47-5 α-Methyl N-phthalyl-L-glutamate γ-aldehyde 
• 131990-87-9 N-(hydroxymethyl)-Cbz-L-BTD-OMe 
• 98303-11-8 (3S, 6S, 9R)-2-oxo-3-phthalimido-7-thia-1-azabicyclo<4.3.0>nonane-9-carboxylic acid 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 104937-58-8 (3S,6S,9R)-2-oxo-3-amino-7-thia-1-aza-bicyclo[4.3.0]nonane-9-carbocylic acid 
• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 131990-88-0 (2R,5S,8S)-1-aza-8-benzyloxycarbonylamino-9-oxo-4-thiabicyclo[3.4.0]nonane-2-carboxylic acid methyl ester 
• 160248-47-5 (3R,6S,8aS)-6-Benzyloxycarbonylamino-5-oxo-hexahydro-thiazolo[3,2-a]pyridine-3-carboxylic acid 
• 23632-67-9 (S)-3-[3-(benzyloxycarbonyl)-5-oxooxazolidin-4-yl]propanoic acid 
• 58456-26-1 (S)-4-<2'-(Chloroformyl)ethyl>-5-oxooxazolidin-3-carbonsaeure-benzylester 

Downstream Products

• 1252806-78-2 5-isoxazoyl-Cha-Ile-(3R,6S)-6-amino-3-(4-[aminomethyl]piperidine-1-carbonyl)tetrahydro-2H-thiazolo(3,2-a)pyridin-5(3H)-one 
• 214151-41-4 5H-thiazolo[3,2-a]pyridine-3-carboxamide, N-{3-[(bis-{[(1,1-dimethylethoxy)carbonyl]amino}methylene)amino]propyl}-hexahydro-5-oxo-6-{[(phenylmethyl)sulfonyl]amino}-, (3R-(3α,6α,8aα))-(9Cl) 
• 872035-23-9 (3S,6S,9R,1'R)-3-[9'-fluorenylmethyloxycarbonyl]-9-[(1'-carbamoyl-2'-phenyl)ethyl]carbamoyl-2-oxo-7-thio-1-azabicyclo[4.3.0]nonane 

Relevant articles and documents

Cyclic RGD peptides containing β-turn mimetics

The α(v)β3-receptor, one member of the integrin family, is implicated in angiogenesis and in human tumor metastasis. Spatial screening led to the highly active first-generation peptide c(RGDfV), which shows a βII'/γ-turn arrangement with D-Phe

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