149572-97-4

Basic information

• Product Name: (R)-3-Amino-2-oxetanone p-toluenesulfonic acid salt
• Synonyms: (R)-3-Amino-2-oxetanone p-toluenesulfonic acid salt;(R)-3-aminooxetan-2-one 4-methylbenzenesulfonate;(3R)-3-Amino-2-oxetanone 4-methylbenzenesulfonate;(R)-3-AMino-1-oxetanone p-toluenesulfonic acid salt;(3R)-3-Aminooxetan-2-one
• CAS NO: 149572-97-4
• Molecular Formula: C10H13NO5S
• Molecular Weight: 0
• Mol File: 149572-97-4.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: (R)-3-Amino-2-oxetanone p-toluenesulfonic acid salt(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-Amino-2-oxetanone p-toluenesulfonic acid salt(149572-97-4)
• EPA Substance Registry System: (R)-3-Amino-2-oxetanone p-toluenesulfonic acid salt(149572-97-4)

Safety Data

• Hazardous Substances Data: 149572-97-4(Hazardous Substances Data)

Usage

General Description

(R)-3-Amino-2-oxetanone p-toluenesulfonic acid salt is a chemical compound that is a salt of (R)-3-Amino-2-oxetanone and p-toluenesulfonic acid. (R)-3-Amino-2-oxetanone p-toluenesulfonic acid salt is used in the synthesis of pharmaceuticals and can act as a chiral building block for the production of various organic compounds. It is also used as a reagent in chemical reactions to introduce the (R)-3-Amino-2-oxetanone moiety into molecules. The p-toluenesulfonic acid salt form of this compound helps to improve its stability and solubility, making it easier to handle and use in various applications. (R)-3-Amino-2-oxetanone p-toluenesulfonic acid salt is important in the field of organic chemistry and pharmaceutical research, and its properties and reactivity make it a valuable tool for chemical synthesis.

Upstream product

• 98541-64-1 N-(tert-butyloxycarbonyl)-D-serine β-lactone 
• 104-15-4 toluene-4-sulfonic acid 
• 98541-64-1 (S)-3-(tert-butoxycarbonylamino)-oxetan-2-one 
• 3262-72-4 (S)-N-(tert-butoxycarbonyl)serine 
• 88109-06-2 3(S)-<(triphenylmethyl)amino>-2-oxetanone 

Downstream Products

• 105661-40-3 L-azidoalanine hydrochloride 

Relevant articles and documents

Compositions and methods of inhibiting N-acylethanolamine-hydrolyzing acid amidase

Compounds and pharmaceutical compositions are contemplated that inhibit N-acyl-ethanolamine-hydrolyzing acid amidase (NAAA) to so increase the concentration of the substrate of NAAA, palmitoylethanolamide (PEA). NAAA inhibition is contemplated to be effec

Synthesis and structure - Activity relationships of N -(2-Oxo-3-oxetanyl) amides as N -acylethanolamine-hydrolyzing acid amidase inhibitors

The fatty acid ethanolamides (FAEs) are a family of bioactive lipid mediators that include the endogenous agonist of peroxisome proliferator- activated receptor-α, palmitoylethanolamide (PEA). FAEs are hydrolyzed intracellularly by either fatty acid amide hydrolase or N-acylethanolamine- hydrolyzing acid amidase (NAAA). Selective inhibition of NAAA by (S)-N-(2-oxo-3-oxetanyl)-3-phenylpropionamide [(S)-OOPP, 7a] prevents PEA degradation in mouse leukocytes and attenuates responses to proinflammatory stimuli. Starting from the structure of 7a, a series of β-lactones was prepared and tested on recombinant rat NAAA to explore structure-activity relationships (SARs) for this class of inhibitors and improve their in vitro potency. Following the hypothesis that these compounds inhibit NAAA by acylation of the catalytic cysteine, we identified several requirements for recognition at the active site and obtained new potent inhibitors. In particular, (S)-N-(2-oxo-3-oxetanyl)biphenyl-4-carboxamide (7h) was more potent than 7a at inhibiting recombinant rat NAAA activity (7a, IC50 = 420 nM; 7h, IC50 = 115 nM) in vitro and at reducing carrageenan-induced leukocyte infiltration in vivo.

Enterobactin and enantioenterobactin

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