149586-32-3

Basic information

• Product Name: 2-Butenoicacid,4-(dimethylamino)-,(E)-(9CI)
• Synonyms: 2-Butenoicacid,4-(dimethylamino)-,(E)-(9CI);4-DiMethylaMino-but-2-enoic acid;Trans-4-diMethylaMinocrotonic acid;(E)-4-(Dimethylamino)-2-butenoic acid;2-Butenoicacid,4-(dimethylamino)
• CAS NO: 149586-32-3
• Molecular Formula: C₆H₁₁NO₂
• Molecular Weight: 129.16
• Product Categories: AMINETERTIARY
• Mol File: 149586-32-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 235.2±23.0 °C(Predicted)
• Appearance: /
• Density: 1.049±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.70±0.10(Predicted)
• CAS DataBase Reference: 2-Butenoicacid,4-(dimethylamino)-,(E)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butenoicacid,4-(dimethylamino)-,(E)-(9CI)(149586-32-3)
• EPA Substance Registry System: 2-Butenoicacid,4-(dimethylamino)-,(E)-(9CI)(149586-32-3)

Safety Data

• Hazardous Substances Data: 149586-32-3(Hazardous Substances Data)

Usage

General Description

2-Butenoic acid, 4-(dimethylamino)-, (E)-(9CI) is a chemical compound with the molecular formula C8H13NO2. It is also known as dimethylamino crotonic acid and is a derivative of crotonic acid. The compound is categorized as an unsaturated carboxylic acid and contains a dimethylamino substituent at the 4-position of the butenoic acid. It is commonly used in organic synthesis and could potentially have various industrial and pharmaceutical applications. Additionally, its E configuration indicates that the two substituent groups on the double bond are on opposite sides, providing important information for its chemical reactivity and behavior.

Upstream product

• 88239-39-8 γ-bromocrotonate de trimethylsilyle 
• 1259519-60-2 4-dimethylaminocrotonic acid methyl ester hydrochloride 

Downstream Products

• 1328624-18-5 (E)-N-((2-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)pyrimidin-5-yl)oxazol-4-yl)methyl)-4-dimethylaminobut-2-enamide 
• 1613228-48-0 (E)-N-(2-(3-(4-(dimethylamino)but-2-enamido)phenylamino)-pyrimidin-5-yl)-2-methyl-5-(3-(trifluoromethyl)benzamido)-benzamide 
• 1453199-18-2 (E)-4-(dimethylamino)-N-(4-methoxy-3-(4-(pyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-ylamino)phenyl)but-2-enamide 
• 1453199-15-9 (E)-N-(3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)-4-methoxyphenyl)-4-(dimethylamino)but-2-enamide 
• 1453199-44-4 (E)-N-(3-(5-cyano-4-(pyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-ylamino)-4-methoxyphenyl)-4-(dimethylamino)but-2-enamide 
• 1056149-69-9 (2E)-(N,N-dimethylamino)-2-butenoyl chloride 

Relevant articles and documents

Trans - 4 - dimethyl amino-crotonic acid and salt preparation method

The invention relates to a preparation method of trans-4-dimethylaminocrotonic acid and its salt and belongs to the field of organic synthesis. The preparation method comprises the following steps that 1, a compound VI (aniline derivative) and a compound V (diethylphosphonoacetic acid) undergo an aminolysis reaction to produce an intermediate IV, 2, the intermediate IV and a compound III ((dimethylamino)-glyoxyl-diethylacetal) undergo a condensation reaction to produce an intermediate II, and 3, the intermediate II undergoes a hydrolysis reaction to produce a desired compound I. The preparation method are simple and efficient synthesis route, is convenient for operation, is free of use of lower-boiling point dangerous chemical dimethylamine, is economic and environmentally friendly, has a high total yield, realizes good product purity and is suitable for industrial production.

Antineoplastic combinations

This invention provides the use of a combination of CCI-779 and EKB-569 in the treatment of neoplasms.