149589-34-4

Upstream product

• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 1660-94-2 Tetraethyl methylenediphosphonate 
• 1315481-74-3 diethyl ((4-(trifluoromethyl)phenyl)ethynyl)phosphonate 
• 762-04-9 phosphonic acid diethyl ester 

Downstream Products

• 1436429-31-0 tetraethyl 1,2-epoxy-2-(4-trifluoromethylphenyl)ethyl bisphosphonate 
• 1315613-64-9 (2S,3R)-methyl 2-amino-4,4-bis(diethoxyphosphoryl)-3-(4-(trifluoromethyl)phenyl)butanoate 

Relevant academic research and scientific papers

Dioxirane oxidation of 2-Aryl-1-vinyl-1, 1-diphosphane dioxide: A convenient approach for the synthesis of novel 1,2-epoxy-2-aryl ethylgembisphosphonates

The synthesis of tetraethyl 1,2-epoxy-2-aryl ethylgembisphosphonates by direct epoxidation of 2-aryl,vinyl-1,1-diphosphonate derivatives with ethyl methyldioxirane generated in situ from potassium hydrogen monopersulfate (caroate) and butanone in a phase

A Facile Cu(I)/TF-BiphamPhos-catalyzed asymmetric approach to unnatural α-amino acid derivatives containing gem-bisphosphonates

A novel catalytic asymmetric Michael addition of azomethine ylide with β-substituted alkylidene bisphosphates was realized in the presence of a chiral copper(I)/TF-BiphamPhos complex. The present system provides a unique and facile access to enantioenriched unnatural α-amino acid derivatives containing gem-bisphosphonates (gem-BPs) in high yields with excellent diastereoselectivities and enantioselectivities. Subsequent transformations lead to the expedient preparation of biologically active unnatural α-amino acid derivatives containing BPs and bisphosphonic acids without loss of diastereo- and enantiomeric excess.

Guanidinoalkyl-1,1-bisphosphonic acid derivatives, process for their preparation and their use

The invention describes tautomeric compounds of the formula Ia, Ib or Ic STR1 and/or their physiologically tolerable salts, in which R1, R2, R3, R4, R5, R6 and R7 are a hydrogen atom, substituted (C1 -C7)-alkyl, (C3 -C10)-cycloalkyl, substituted phenyl or (C1 -C4)-alkylphenyl, R2 is substituted phosphoric acid, R2 and R3, R2 and R5 or R4 and R5 form a monocyclic 5- to 7-membered saturated or unsaturated heterocyclic ring which is mono- or polysubstituted, R8, R9, R10 and R11 are a hydrogen atom or (C1 -C5)-alkyl, X is a hydrogen atom, hydroxyl or halogen, l and n are an integer from 0 to 7, m is an integer from 0 to 2, and the sum of the numbers l, m and n is less than or equal to 10, a process for the preparation of the compounds of the formula Ia, Ib or Ic, pharmaceuticals and their use for the prophylaxis or treatment of osteoporosis.