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149624-22-6

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149624-22-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 149624-22-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,9,6,2 and 4 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 149624-22:
(8*1)+(7*4)+(6*9)+(5*6)+(4*2)+(3*4)+(2*2)+(1*2)=146
146 % 10 = 6
So 149624-22-6 is a valid CAS Registry Number.

149624-22-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Deoxy-2-fluoro-α-D-ribofuranose

1.2 Other means of identification

Product number -
Other names 2'-F-dU Phosphoramidite

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:149624-22-6 SDS

149624-22-6Downstream Products

149624-22-6Relevant articles and documents

Arabinofuranose-derived positron-emission tomography radiotracers for detection of pathogenic microorganisms

Kalita, Mausam,Parker, Matthew F.L.,Luu, Justin M.,Stewart, Megan N.,Blecha, Joseph E.,VanBrocklin, Henry F.,Evans, Michael J.,Flavell, Robert R.,Rosenberg, Oren S.,Ohliger, Michael A.,Wilson, David M.

, p. 231 - 239 (2020/04/15)

PURPOSE: Detection of bacteria-specific metabolism via positron emission tomography (PET) is an emerging strategy to image human pathogens, with dramatic implications for clinical practice. In silico and in vitro screening tools have recently been applied to this problem, with several monosaccharides including l-arabinose showing rapid accumulation in Escherichia coli and other organisms. Our goal for this study was to evaluate several synthetically viable arabinofuranose-derived 18F analogs for their incorporation into pathogenic bacteria. PROCEDURES: We synthesized four radiolabeled arabinofuranose-derived sugars: 2-deoxy-2-[18F]fluoro-arabinofuranoses (d-2-18F-AF and l-2-18F-AF) and 5-deoxy-5-[18F]fluoro-arabinofuranoses (d-5-18F-AF and l-5-18F-AF). The arabinofuranoses were synthesized from 18F- via triflated, peracetylated precursors analogous to the most common radiosynthesis of 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG). These radiotracers were screened for their uptake into E. coli and Staphylococcus aureus. Subsequently, the sensitivity of d-2-18F-AF and l-2-18F-AF to key human pathogens was investigated in vitro. RESULTS: All 18F radiotracer targets were synthesized in high radiochemical purity. In the screening study, d-2-18F-AF and l-2-18F-AF showed greater accumulation in E. coli than in S. aureus. When evaluated in a panel of pathologic microorganisms, both d-2-18F-AF and l-2-18F-AF demonstrated sensitivity to most gram-positive and gram-negative bacteria. CONCLUSIONS: Arabinofuranose-derived 18F PET radiotracers can be synthesized with high radiochemical purity. Our study showed absence of bacterial accumulation for 5-substitued analogs, a finding that may have mechanistic implications for related tracers. Both d-2-18F-AF and l-2-18F-AF showed sensitivity to most gram-negative and gram-positive organisms. Future in vivo studies will evaluate the diagnostic accuracy of these radiotracers in animal models of infection.

Substituent effects of the pH-independent hydrolysis of 2'-substituted nicotinamide arabinosides

Handlon,Oppenheimer

, p. 5009 - 5010 (2007/10/02)

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