149648-10-2Relevant academic research and scientific papers
METAL COMPLEXES HAVING DUAL HISTONE DEACETYLASE INHIBITORY AND DNA-BINDING ACTIVITY
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Page/Page column 37, (2011/02/24)
Compounds comprising a metal complex having the structure [X-Y-Z-Mn+]p+. B are disclosed in which X is a histone deacetylase inhibitor, Mn+ is a DNA -binding heavy metal ion, Y is an aliphatic or aromatic spacer or is absent, and Z is a mono- or bi-dentate or chelating donor linker, or a bridging linker, P+ designates the charge on the complex ion, which may be positive, negative or absent and B is a counterion or is absent. The linker Z is labile and its metal complex X-Y-Z-Mn+ is capable of being hydrolysed in-vivo. The compounds find application in the treatment of cancer.
