149648-70-4Relevant academic research and scientific papers
MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF
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Page/Page column 128, (2010/11/05)
The present application relates to 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,4]benzodiazepine, 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,5]benzodiazepine, 2,3,4,4a,5,6,7,11b-octahydro-1H-pyrido[3,4-d][2]benzazepine, 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1]benzazepine, 1,2,3,4,4a,5-hexahydro-7H-pyrazino[1,2-a][4,1]benzoxazepine, and 2,3,4,4a,5,6-hexahydro-1H-pyrazino[2,1-d][1,5]benzoxazepine, and 5,6,7,7a,8,9,10,11-octahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazepine derivatives of formula (I) wherein R1, R2, R3, R4, R5, R6, X1, X2, X3, X4, Y1, Y2, and Y3 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
Aminomethylpiperazines as selective urotensin antagonists
Hilfiker, Mark A.,Zhang, Daohua,Dowdell, Sarah E.,Goodman, Krista B.,McAtee, John J.,Dodson, Jason W.,Viet, Andrew Q.,Wang, Gren Z.,Sehon, Clark A.,Behm, David J.,Wu, Zining,Carballo, Luz H.,Douglas, Stephen A.,Neeb, Michael J.
scheme or table, p. 4470 - 4473 (2009/04/06)
Aminomethylpiperazines, reported previously as being κ-opioid receptor agonists, were identified as lead compounds in the development of selective urotensin receptor antagonists. Optimized substitution of the piperazine moiety has provided high affinity u
A potent new class of κ-receptor agonist: 4-Substituted 1-(arylacetyl)- 2-[(dialkylamino)methyl]piperazines
Naylor,Judd,Lloyd,Scopes,Hayes,Birch
, p. 2075 - 2083 (2007/10/02)
The synthesis of 4-substituted 1-(arylacetyl)-2- [(alkylamino)methyl]piperazines (10-22, 26, 27, and 30-33) and their activities as κ-opioid receptor agonists are described. This includes a range of 4-acyl and 4-carboalkoxy derivatives with the latter ser
