149649-08-1Relevant academic research and scientific papers
Potent and selective ligands for adenosine binding sites
Cristalli,Camaioni,Di Francesco,Eleuteri,Vittori,Volpini
, p. 1379 - 1388 (1997)
A number of selective ligands for the different binding sites of adenosine have been synthesized and tested in several pharmacological models. The aim of these synthetic efforts is both to improve the knowledge of structure-activity relationships in the adenosine-related biological systems and to develop drugs from some of these molecules.
Synthesis of 2'-deoxyribonucleoside derivatives of 1-deazapurine
Cristalli,Vittori,Eleuteri,Volpini,Camaioni,Lupidi
, p. 835 - 848 (2007/10/02)
5,7-Dichloro-3H-imidazo[4,5-b]pyridine (4) is a versatile base which can be coupled with a variety of sugar moieties and transformed in a series of 7- alkyl(aryl)amino-derivatives by reacting with the corresponding amines. In this paper synthesis, structure elucidation and ADA inhibitory activity of 2'-deoxyribonucleoside derivatives of N6-substituted 1-deazaapurines are described.
