149652-52-8

Upstream product

• 120-72-9 indole 
• 1207875-22-6 1-azido-2-(prop-2-ynyl)benzene 
• 16714-25-3 2-azidobenzaldehyde 
• 589-87-7 1,4-bromoiodobenzene 
• 1534360-76-3 2-(prop-2-yn-1-yl)aniline 
• 589-15-1 1-bromomethyl-4-bromobenzene 

Relevant academic research and scientific papers

Protocols for the Syntheses of 2,2′-Bis(indolyl)arylmethanes, 2-Benzylated Indoles, and 5,7-Dihydroindolo[2,3- b]carbazoles

The electrophilic substitution reaction of 4,7-dihydroindole with aryl-aldehydes as an electrophilic partner followed by an oxidation step to deliver 2,2′-bis(indolyl)arylmethanes was studied for the first time. The reaction afforded regioselectivity at the 2,2′-positions of indole in an operationally simple and inexpensive procedure with a variety of substrates. To the best of our knowledge, this is the first set of examples of 2,2′-bis(indolyl)arylmethanes obtained in a substituent-free manner. A facile method from dipyrromethanes to the corresponding 2-benzylindoles was also reported. In addition, 2,2′-bis(indolyl)arylmethanes were converted to 5,7-dihydroindolo[2,3-b]carbazoles.

Facile synthesis of 2-arylmethylindoles and 2-vinylic indoles through palladium-catalyzed heteroannulations of 2-(2-propynyl)aniline and 2-(2-propynyl)tosylanilide

A facile method for the general synthesis of 2-arylmethylindoles has been developed through the reaction of 2-(2-propynyl)aniline or 2-(2-propynyl) tosylanilide with aryl iodides in the presence of Pd(OAc)2, PPh 3, and DBU. 2-(2-Propynyl)tosylanilide is found to be reactive also towards electron deficient alkenes in the presence of Pd(OAc)2 and sodium iodide under an oxygen atmosphere, providing easy access to 2-vinylic indoles which possess exclusive E-stereochemistry in the side chain double bond. Operational simplicity, compatibility of the various functional groups, and ease of product formation are the hallmarks of these methods. A mechanism has been proposed to explain the product formation.

Facile synthesis of 2-benzylindoles

A wide range of 2-Benzylindoles 2 are conveniently and efficiently prepared by heating N-benzylindoles 1 in polyphosphoric acid. Mechanistic studies suggest an intramolecular rearrangement via the corresponding 3- benzyl intermediates.

Substituted indole derivatives

Compounds of the Formula (I), (II), or (III): STR1 wherein the variables are as defined in the specification and the pharmaceutically acceptable salts thereof, exhibit useful pharmacological properties, and are particularly useful as angiotensin II antago

Substituted indole antagonists derivatives which are angiotensin II

Compound of the Formula (I), (II), or (III): STR1 wherein: R 1 is lower alkyl or 2""-(1H-tetrazol-5-yl)biphenyl-4''-ylmethyl;R 2 is lower alkyl when R 1 is 2""-(1H-tetrazol-5-yl)biphenyl-4''-ylmethyl; or R 2 is 2""-(1H-tetrazol-5-yl)biphenyl-4''-ylmethyl